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Boston Medical Center’s Hepatobiliary and Pancreatic Tumor Program was established in 2008 to effectively treat the growing number of patients being diagnosed with cancers of the liver, biliary tree, gallbladder, and pancreas.

In a highly supportive and collaborative environment, physicians who are nationally recognized leaders in the care of patients with all stages of liver cancer provide patients with the most advanced, coordinated, and comprehensive medical care available—treatment that is effective and innovative in curing and controlling cancer and managing its impact on quality of life.

At BMC, diagnosis and treatment of patients with liver cancer combine the resources of a multidisciplinary clinical center dedicated to personal, patient-focused care with the state-of-the-art expertise and technological advances of a major teaching hospital. As the primary teaching affiliate of the Boston University School of Medicine, BMC is at the forefront of clinical practice, surgical expertise, and research in oncology.

What Is Liver Cancer?

Liver cancer is a type of cancer that is caused by the abnormal growth of cells in the liver.

The liver is the largest organ in the abdomen. It is located on the right side of the body, behind the right ribs and below the right lung. It is divided into left and right lobes.

The liver gets its blood supply from two sources: the hepatic artery, which supplies the liver with oxygen-rich blood, and the portal vein, which supplies the liver with nutrient-rich blood from the intestines. The portal vein is the liver’s primary source of blood.

The liver performs several functions. It breaks down toxic substances in the blood and gets rid of them. It produces enzymes and bile that help digest food and turn it into substances the body needs to sustain itself and grow. It also produces proteins and clotting factors important in healing.

Growths in the liver can be benign (noncancerous) or malignant (cancerous). Benign growths are generally not life threatening, can often be removed, and do not spread to distant sites in the body. Malignant growths can spread to distant sites in the body and may be life threatening.

The two types of liver cancers are primary liver cancers and secondary liver cancers.

Primary Liver Cancers

Primary liver cancers are cancers that begin in the liver. There are several types of primary liver cancers, but the two most common are:

  • Hepatocellular carcinoma (HCC): Hepatocellular carcinoma, also called malignant hepatoma, develops in the hepatocytes (the main type of liver cell). It is the most common form of liver cancer in adults. Approximately 4 out of 5 primary liver cancers are HCCs (American Cancer Society 2015).
  • Intrahepatic cholangiocarcinoma (bile duct cancer): Intrahepatic cholangiocarcinoma develops from cholangiocytes (bile duct cells) located inside the liver. These cholangiocytes line the bile ducts, which facilitate excretion of bile produced by the liver. Intrahepatic cholangiocarcinoma accounts for 1 or 2 out of every 10 cases of liver cancer (American Cancer Society 2015).

Secondary Liver Cancers

Secondary liver cancers are cancers that develop in other parts of the body and metastasize (spread) to the liver. The most common of these is cancer of the gastrointestinal tract, like colon cancer. These cancers often require multiple specialists in order to achieve the best survival. Even though these are metastatic cancers, many times the potential of cure is still possible.

Primary liver cancers are the focus of the rest of these pages.

Symptoms of Liver Cancer

Many early-stage liver cancers do not cause symptoms, with symptoms only developing with progression. Common symptoms include:

  • Abdominal pain
  • A bulge on the right side
  • Unintentional weight loss
  • Lack of appetite
  • Feeling full without eating a lot
  • Nausea and vomiting
  • Bloating
  • Fever
  • Yellowing of the eyes (icterus)
  • Yellowing of the skin (jaundice), pale stools, and dark urine
  • Fatigue

Many of these symptoms can be caused by health problems other than liver cancer. Patients experiencing any of these symptoms should see their physician.

Causes of Liver Cancer

Although the exact causes of liver cancer remain unknown, certain risk factors connected to the disease have been identified. A risk factor is anything that affects one’s chance of getting a disease. While risk factors may be useful in identifying high-risk individuals, they do not determine whether a person develops a disease. Some risk factors, such as alcohol consumption, are within the individual’s control, while others, such as gender, are not.

Possible risk factors for liver cancer include:

  • Gender: Men develop liver cancer more often than women.
  • Ethnicity: Asian Americans and Pacific Islanders have the highest risk of developing liver cancer.
  • Location: The disease is less prevalent in the United States than in other places in the world, such as countries in sub-Saharan Africa and Southeast Asia.
  • Hepatitis B virus (HBV) or Hepatitis C virus (HCV): Long-term infection with either of these viruses may increase a person’s risk of developing liver cancer.
  • Hemochromatosis: Hemochromatosis is a disease that causes the body to take up and store too much iron. The body stores the excess iron in the heart, liver, and pancreas. The disease may be hereditary (passed on from one’s parents), or it may result from blood transfusions. Having hemochromatosis may increase a person’s risk of developing liver cancer.
  • Cirrhosis: Cirrhosis is a disease that develops when liver cells become damaged and are replaced by scar tissue. Infection with HBV and HCV, heavy alcohol consumption, hemochromatosis, and certain drugs and parasites can all cause liver damage. People with cirrhosis are prone to developing liver cancer.
  • Environmental factors and toxins: Several environmental factors, such as aflatoxin (a toxic substance produced by certain types of mold that grows on some foods), and toxins, such as tobacco, alcohol, and solvent vinyl chloride (a substance used in the production of plastics), can increase a person’s risk of developing liver cancer.
  • Anabolic steroids: Using anabolic steroids (substances that act like the male hormone testosterone) may put a person at greater risk of developing liver cancer.
  • Obesity and diabetes: Being obese (very overweight) or having type 2 diabetes may increase a person’s risk of developing the disease.

References

American Cancer Society. 2015. Liver Cancer Overview. PDF. http://www.cancer.org/acs/groups/cid/documents/webcontent/003058-pdf.pdf

National Cancer Institute. 2009. What You Need To Know About™ Liver Cancer. PDF. Bethesda: National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services. http://www.cancer.gov/publications/patient-education/liver.pdf

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