The least common type of biopsy, a surgical (or open) biopsy is generally used to remove all or part of the lump for examination under a microscope. When the whole lump is removed, the surgeon may also remove some of the surrounding healthy tissue. Surgical biopsies are generally performed in the hospital’s outpatient centers. Local anesthesia is used in combination with other drugs to make you relaxed and drowsy. The procedure can also be done using general anesthesia.