Addiction Research

BMC has the distinction of being the recipient of the largest grant awarded by the US government to combat the opioid epidemic.  Scientists from the nation’s leading health agencies and four major academic institutions are partnering with communities in four states to test a set of interventions to combat the opioid crisis. The ambitious HEALing Communities Study aims to reduce opioid overdose deaths by 40 percent over 3 years in participating communities.  The Massachusetts team is led by Grayken faculty member Dr. Jeffrey Samet, Chief of BMC’s Section of General Internal Medicine.  The study website shows the communities that are partnering with BMC to implement measures that are aimed at drastically cutting deaths from opioid overdose in the next few years.

Learn more about the HEALing Communities Study

For more information, contact Carly Bridden, MA, MPH, HEALing Communities Study, Carly.Bridden@bmc.org

The "Targeting Effective Analgesia in Clinics for HIV" (TEACH) Study RCT tests whether a collaborative care intervention for physicians improves the delivery of chronic opioid therapy for HIV-infected persons.

Learn more about TEACH

This qualitative research study focuses on how the COVID-19 pandemic has influenced substance use professionals’ experiences in providing outpatient therapy for opioid use disorder in Massachusetts. Eligible participants will have worked for two or more years in outpatient therapy for opioid use disorder, with at least one of those years during the COVID-19 pandemic. Broadly, the purpose of this research study is to explore the intersection between the Massachusetts’ opioid epidemic and the COVID-19 pandemic through the perspective of substance use professionals, as well as provide a means to gather insights into outpatient therapy modalities adopted during the pandemic.

Interested professionals may contact Caitlyn Leonard at caitlynl@bu.edu or (978) 826-3959. Compensation is available

The NIDA-funded Research in Addiction Medicine Scholars (RAMS) Program will develop skills in addiction medicine research among physicians from ABAM Foundation-accredited addiction medicine fellowship programs or addiction psychiatry fellowship programs across the United States. The RAMS Program will make important contributions to the development of the next generation of addiction physician researchers in order to provide better care for patients with and at risk for addictive diseases.

Learn more about RAMS

More than 120 babies are born at BMC each year to women with opioid use disorders. Researchers in the Departments of Pediatrics & Obstetrics and Gynecology are busy discovering new and better treatments for these vulnerable infants, many of whom are develop Neonatal Abstinence Syndrome (NAS). All babies born to with in-utero opioid exposure are monitored as inpatients for 5-7 days for symptoms of opioid withdrawal. The most recent available data suggest that twelve percent of all NAS babies in the state are cared for by BMC.

The RESPECT Research Group is learning about the short-term medical and long-term developmental outcomes of treating these newborns with different pharmacologic regimens. The groundbreaking studies conducted by the RESPECT Research Group are resulting in many publications, leading the way to higher quality, more personalized care for babies exposed to opioids during pregnancy.

Recent studies and publications have focused on the impact of buprenorphine or naltrexone treatment on NAS outcomes, the impact of genetic variants on NAS outcomes, the influence of clinical factors such as prematurity and breastfeeding on NAS outcomes, and the importance of non-pharmacologic care on NAS outcomes.

Learn more about RESPECT

The St PETER HIV trial will to compare the effects of two nicotinic receptor partial agonists, varenicline and cytisine, on alcohol consumption, alcohol craving, smoking, inflammation, CHD risk and mortality risk.

Learn more about St PETER

There is evidence to suggest that many individuals suffering from opioid use disorders become addicted after having been legally prescribed opioids by a physician as a treatment for chronic pain. In all-too-many cases, prescription opioid use escalates to a heroin addiction, as heroin is cheaper and easier to access than prescription opioids.

The purpose of TOPCARE (Transforming Opioid Prescribing in Primary Care) is to bring change in the way primary care services are delivered and decrease misuse of, and addiction to, prescription opioids.

With federal research funding, BMC physician researchers are examining the impact of opioid prescribing guidelines for chronic pain to determine whether adherence to these guidelines reduces opioid misuse. The TOPCARE program trains physicians to adhere to prescribing guidelines and then follows up with physicians implementing the guidelines to continue to improve prescribing of targeted drugs.

TOPCARE is expected to improve patient care, prevent addiction, and reduce healthcare costs.

Learn more about TOPCARE

Bagley, S. M., Schoenberger, S. F., dellaBitta, V., Lunze, K., Barron, K., Hadland, S. E., & Park, T. W. (2022). An Exploration of Young Adults With Opioid use Disorder and How Their Perceptions of Family Members' Beliefs Affects Medication Treatment. Journal of addiction medicine, 10.1097/ADM.0000000000001001. Advance online publication. https://doi.org/10.1097/ADM.0000000000001001

Kim, T. W., Samet, J. H., Lodi, S., Kimmel, S. D., Forman, L. S., Lira, M. C., Liebschutz, J. M., Williams, E. C., & Walley, A. Y. (2022). Functional Impairment and Cognitive Symptoms Among People with HIV Infection on Chronic Opioid Therapy for Pain: The Impact of Gabapentin and Other Sedating Medications. AIDS and behavior, 10.1007/s10461-022-03716-3. Advance online publication. https://doi.org/10.1007/s10461-022-03716-3

Zhong, H., Brandeau, M. L., Yazdi, G. E., Wang, J., Nolen, S., Hagan, L., Thompson, W. W., Assoumou, S. A., Linas, B. P., & Salomon, J. A. (2022). Metamodeling for Policy Simulations with Multivariate Outcomes. Medical decision making : an international journal of the Society for Medical Decision Making, 272989X221105079. Advance online publication. https://doi.org/10.1177/0272989X221105079

Epstein, R. L., Wang, J., White, L. F., Kapadia, S. N., Morgan, J. R., Bao, Y., & Linas, B. P. (2022). Medicaid Hepatitis C Virus Treatment Policies: Impact on Testing and Treatment in the Commercially Insured. American journal of preventive medicine, S0749-3797(22)00161-1. Advance online publication. https://doi.org/10.1016/j.amepre.2022.03.010

Dey, A. K., Ennis, N., Cheng, D. M., Blokhina, E., Raj, A., Quinn, E., Bendiks, S., Palfai, T., Dunne, E. M., Cook, R. L., Krupitsky, E., & Samet, J. H. (2022). Impulsivity and linkage to HIV Care among People living with HIV in St. Petersburg, Russia. AIDS and behavior, 10.1007/s10461-022-03738-x. Advance online publication. https://doi.org/10.1007/s10461-022-03738-x

Romero-Rodríguez, E., Chen, C. A., Dukes, K. A., Hartlage, K., Palfai, T. P., Magane, K. M., Samet, J. H., & Saitz, R. (2022). Cannabis and cocaine use, drinking outcomes, and quality of life in general hospital inpatients with alcohol use disorder. Substance abuse, 43(1), 1225–1230. https://doi.org/10.1080/08897077.2022.2074592

Zhang, K., Strahan, A. E., Guy, G. P., & Larochelle, M. R. (2022). Trends in Concurrent Opioid and Benzodiazepine Prescriptions in the United States, 2016 to 2019. Annals of internal medicine, 10.7326/M21-4656. Advance online publication. https://doi.org/10.7326/M21-4656

Borrelli, K. N., Wachman, E. M., Beierle, J. A., Taglauer, E. S., Jain, M., Bryant, C. D., & Zhang, H. (2022). Effect of Prenatal Opioid Exposure on the Human Placental Methylome. Biomedicines, 10(5), 1150. https://doi.org/10.3390/biomedicines10051150