Sickle Cell Disease
Hematology
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Sickle cell disease (SCD) is a chronic, genetic blood disorder which causes painful attacks (sickle cell crises) that can be difficult for patients to manage. Patients with SCD over their lifetime can have problems which affect practically every part of the body. SCD changes normal, round red blood cells into ones shaped like crescent or half-moons. Normally, healthy red blood cells carry oxygen through the body. However, people with SCD do not have enough normal cells to carry the right amount of oxygen. This causes the sickled cells to get stuck and block blood vessels, which stops the oxygen from getting through the body and causes a lot of pain. When there is a blockage, the hands, feet, abdomen, back, or chest are affected.
Along with pain, symptoms of SCD can include fatigue, shortness of breath, rapid heart rate, paleness or jaundice, swelling of the hands or feet, and an increased rate of infections. Sometimes, SCD can lead to damage of many organs throughout the body, delayed growth, vision problems, and strokes.
Center of Excellence in Sickle Cell Disease
BMC’s Center of Excellence in Sickle Cell Disease is the largest center of its kind in New England, serving more than 450 patients annually, from newborns to adults. The center’s multidisciplinary team is committed to providing patients across their lifespan with highly personalized care to manage their symptoms associated with the disease so they can live as normal a life as possible.
The SCD team includes physicians and a nurse practitioner from pediatric and adult hematology, adult and pediatric primary care, and other specialties as well as nurses, social workers, case management and a patient navigator to help guide patients through their care. The program focuses on providing consistent care between the Emergency Department, inpatient services, and outpatient clinics. The program utilizes the pediatric STAR unit and the Infusion Center in the adult Hematology/Oncology clinic for outpatient transfusions and pain management.
Features of the Center
- Largest combined SCD pediatric and adult population within one center in New England
- Studying how sickle cell disease affects the body and investigating new potential treatments
- Expertise in the transition of care from pediatrics to adulthood
- Expertise in management of the complications of SCD with medical and surgical specialists who treat our patients
- Expertise in pain management
- Continued development of new initiatives to improve patient care
Contact Us
3rd Floor
Moakley Building 617.638.6428
Specialty Clinics
Hematology
Patients with blood disorders receive consultation and treatment for a broad range of benign conditions, such as hemoglobinopathies (sickle cell anemia and thalassemia), hemochromatosis, bleeding and thrombotic disorders (von Willebrand's disease and hemophilia), hypercoagulable states, myeloproliferative disorders, myelodysplasia and anemia, and malignancies such as leukemia, lymphoma and myeloma.
Treatments & Services
Treatment of Sickle Cell Disease
Treatment of young patients usually includes antibiotics from 2 months to 5 years of age to help prevent infections. Children and adults should be seen regularly in the outpatient clinic to assess for symptoms, screen for complications of the disease and promote general health and well-being. We recommend appropriate immunizations across the lifespan. Many patients living with SCD experience pain on a daily basis and using the right combination of therapies can help to treat this. Developing a pain management plan with a physician or pain management specialist is encouraged at the center.
Diagnostics and Tests
Sickle cell disease can be diagnosed by a blood test. Every state requires that all babies, before they leave the hospital, are tested for SCD as part of their newborn screening.
Our Team
Elizabeth S Klings, MD
Adult Clinic
Lillian E McMahon, MD
Pediatric Clinic
Robyn T Cohen, MD
Associate Professor of Pediatrics, Boston University School of Medicine
Patricia L Kavanagh, MD
Caitlin M Neri, MD
Amy E Sobota, MD, MPH

Hematologists
Lillian E McMahon, MD
Additional Information
Research Overview
The physicians and staff of the BMC’s Center of Excellence in Sickle Cell Disease are also affiliated with the Boston University School of Medicine (BUSM). For more information on research studies, please visit the Center of Excellence in Sickle Cell Disease BUSM website.