A diabetic foot ulcer is an open sore or wound that can occur in patients with diabetes and is commonly located on the bottom of the foot. Ulcers that become infected, result in most patients having to be hospitalized, increase the risk of potential lower extremity amputation and in extreme cases, may cause death. More than 25 million people in the United States are estimated to have diabetes mellitus (DM). Of those 25 million, 15–25% will develop a diabetic foot ulcer during their lifetime.