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Participate in Research or Clinical Trials

For general information about participating in research, see http://www.bumc.bu.edu/ohra/for-research-participants/ and https://www.bmc.org/research-operations/participate-research.

If you have any questions or do not see the study you are interested in, please contact the Clinical Trial Office at [email protected].

Project Title Link Principal Investigator Department Section E-mail Phone
PHARMACOKINETIC PROPERTIES OF ANTIRETROVIRAL AND RELATED DRUGS DURING PREGNANCY AND POSTPARTUM (IMPAACT P1026S) Mark Mirochnick Pediatrics Pediatric Infectious Diseases 617-414-5813
INTRAMEDULLARY NAILS VERSUS PLATE FIXATION RE-EVALUATION STUDY IN PROXIMAL TIBIA FRACTURES: A MULTICENTER RANDOMIZED TRIAL COMPARING IM NAILS AND PLATE FIXATION (I.M.P.R.E.S.S) Paul Tornetta Orthopaedic Surgery Orthopaedic Surgery 617-414-6295
RTOG #R0534: A Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPPORT) in Prostate Cancer Patients with a Rising PSA After Radical Prostatectomy Ariel Hirsch Radiation Oncology N/A 617-638-8260
RTOG #R0920: A PHASE III STUDY OF POSTOPERATIVE RADIATION THERAPY (IMRT) +/- CETUXIMAB FOR LOCALLY-ADVANCED RESECTED HEAD AND NECK CANCER Minh-Tam Truong Radiation Oncology N/A 617-638-8260
A Randomized, Double-blind, Placebo-Controlled, Phase II Multicenter Trial of a Monoclonal Antibody to CD20 (Rituximab) for the Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH) Robert Simms Medicine Pulmonary, Allergy and Critical Care 617-414-2507
THE PARKINSON'S PROGRESSION MARKERS INITIATIVE Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
PHASE I/II, MULTI-CENTER, OPEN-LABEL PHARMACOKINETIC, SAFETY, TOLERABILITY AND ANTIVIRAL ACTIVITY OF GSK1349572, A NOVEL INTEGRASE INHIBITOR, IN COMBINATION REGIMENS IN HIV-1 INFECTED INFANTS, CHILDREN AND ADOLESCENTS (IMPAACT P1093) Stephen Pelton Pediatrics Pediatric Infectious Diseases 617-414-5813
A Phase II Multi-Center Study of High-Dose Cyclophosphamide and Antithymocyte Globulin Followed by Autologous Hematopoietic Cell Transplantation with Post Transplant Maintenance for the Treatment of Systemic Sclerosis Robert Simms Medicine Rheumatology 617-638-4475
International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA Trial Protocol) Claudia Hochberg Medicine Cardiology 617-638-8716
FEASIBILITY/OUTCOMES STUDY OF HYPOFRACTIONATED STEREOTACTIC BODY RADIATION THERAPY AS A BOOST TO THE PROSTATE FOR TREATMENT OF LOCALIZED, NON-METASTATIC, HIGH RISK PROSTATE CANCER Ariel Hirsch Radiation Oncology N/A 617-638-8260
Millennium C16011: A Phase 3, Randomized, Controlled, Open-label, Multicenter, Safety and Efficacy Study of Dexamethasone Plus MLN9708 or Physician's Choice of Treatment Administered to Patients With Relapsed or Refractory Systemic Light Chain (AL) Amyloidosis Vaishali Sanchorawala Medicine Hematology and Medical Oncology 617-638-8260
SWOG #S1207: Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk, Hormone Receptor-Positive and HER2/neu Negative Breast Cancer Lauren Oshry Cancer Care Center N/A 617-638-8261
A Prospective Randomized Trial to Assess PO versus IV Antibiotics for the Treatment of Early Post-op Wound Infection after Extremity Fractures Paul Tornetta Orthopaedic Surgery Orthopaedic Surgery 617-414-6295
PVD: Phase I Study of Pomalidomide, Bortezomib, and Dexamethasone (PVD) as First-Line Treatment of AL Amyloidosis or Light Chain Deposition Disease Vaishali Sanchorawala Medicine Hematology and Medical Oncology 617-638-8260
AMC #085: A Pilot Trial of AVD and Brentuximab Vedotin (SGN-35) in the treatment of stage II-IV HIV-associated Hodgkin Lymphoma Mark Sloan Medicine Hematology and Medical Oncology 617-638-8213
A PHASE I TRIAL TO EVALUATE THE SAFETY AND PHARMACOKINETICS OF RALTEGRAVIR IN HIV-1-EXPOSED NEONATES AT RISK OF ACQUIRING HIV-1 INFECTION (IMPAACT P1110) Ellen Cooper Pediatrics Pediatric Infectious Diseases 617-414-7466
Improving Pain Management and Long Term Outcomes Following High Energy Orthopedic Trauma Paul Tornetta Orthopaedic Surgery Orthopaedic Surgery 617-414-6295
Supplemental Perioperative Oxygen to Reduce Surgical Site Infection After High Energy Fracture Surgery (OXYGEN) Paul Tornetta Orthopaedic Surgery Orthopaedic Surgery 617-414-6295
Raltegravir Pharmacokinetics and Safety in Neonates (IMPAACT P1097) Ellen Cooper Pediatrics Pediatric Infectious Diseases 617-414-5813
CTSU #E1412: Randomized Phase II Open Label Study of Lenalidomide R-CHOP (R2CHOP) vs RCHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone) in Patients with Newly Diagnosed Diffuse Large B Cell Lymphoma John Sloan Medicine Hematology and Medical Oncology 617-638-8260
A Phase 2/3 Multicenter, Open-Label, Multicohort, Two-Part Study Evaluating the Pharmacokinetics (PK), Safety, and Antiviral Activity of Elvitegravir (EVG) Administered with a Background Regimen (BR) Containing a Ritonavir-Boosted Protease Inhibitor (PI/r) in HIV-1 Infected, Antiretroviral Treatment-Experienced Pediatric Subjects (Gilead GS-US-183-0160) Ellen Cooper Pediatrics Pediatric Infectious Diseases 617-414-5813
Improving Outcomes in Neonatal Abstinence Syndrome (NAS) Michael Silverstein Pediatrics Pediatric General 617-414-3827
An Observational Study of Hepatitis C Virus in Pregnancy (MFMU/NICHD protocol) Stephen Pelton Pediatrics Pediatric Infectious Diseases 617-414-5813
A Multicenter, International, Phase 3, Double-Blind, Placebo-Controlled, Randomized Study to Evaluate the Efficacy, Safety, and Tolerability of Daily Oral Dosing of Tafamidis Meglumine (PF-06291826) 20 mg or 80 mg in Comparison to Placebo in Subjects Diagnosed With Transthyretin Cardiomyopathy (TTR-CM) John Berk Medicine Amyloid Research & Training Program 617-638-4591
Protocol H8A-MC-LZAZ(a)/ADC-040-A4 Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4 Study) Robert Stern Alzheimers Disease Center N/A 617-414-1196
An open label, multicenter study evaluating the Safety and Imaging Characteristics of a new PET Scan Test in Healthly Volunteers, Subjects with Mild Cognitive Impairment and Subjects with Alzheimer's Disease Dementia Robert Stern Alzheimers Disease Center N/A 617-638-5368
A Phase 2/3, Multicenter, Open-label, Multicohort, Two-Part Study Evaluating Pharmacokinetics (PK), Safety, and Efficacy of Cobicistat-boosted Atazanavir (ATV/co) or Cobicistat-boosted Darunavir (DRV/co), Administered with a Background Regimen (BR) in HIV-1 Infected, Treatment-Experienced, Virologically Suppressed Pediatric Subjects (Gilead GS-US-216-0128) Ellen Cooper Pediatrics Pediatric Infectious Diseases 617-414-5813
Randomized, Multicenter, Controlled Trial to Compare Best Endovascular versus Best Surgical Therapy in Patients with Critical Limb Ischemia. Jeffrey Kalish Surgery Vascular and Endovascular Surgery 617-414-6832
The Impact of Diabetes on REvascularization in BEST-CLI (TIDE) Jeffrey Kalish Surgery Vascular and Endovascular Surgery 617-414-6832
Mild and Rapidly Improving Stroke Study (MaRISS) Rafael Jose Romero Neurology Stroke 617-414-1171
Abatacept (CTLA4-Ig) for the Treatment of Relapsing, Non-Severe, Granulomatosis with Polyangiitis (Wegener's) (ABROGATE) Paul Monach Medicine Rheumatology 617-414-2512
NRG #HN001: Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA) Minh-Tam Truong Medicine Hematology and Medical Oncology 617-638-8213
ANCHOR Study: Anal Cancer/ High-grade squamous intraepithelial lesions (HSIL) Outcomes Research Study Elizabeth Stier Obstetrics / Gynecology General Gynecology 323-875-0267
A Clinical Evaluation of Absorb™ BVS, the Everolimus Eluting Bioresorbable Vascular Scaffold in the Treatment of Subjects with de novo Native Coronary Artery Lesions Alice Jacobs Medicine Cardiology 617-638-8716
NRG #BN001: Randomized Phase II Trial of Hypofractionated Dose-Escalated Photon IMRT or Proton Beam Therapy versus Conventional Photon Irradiation with Concomitant and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma Minh-Tam Truong Cancer Care Center N/A 617-638-8261
SWOG #S1320: A Randomized Phase II Trial of Intermittent Versus Continuous Dosing of Dabrafenib (NSC-763760) and Trametinib (NSC-763093) in BRAF V600E/K Mutant Melanoma Adam Lerner Medicine Hematology and Medical Oncology 617-638-8213
A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects with Staphylococcus aureus Bacteremia Including Infective Endocarditis Manish Sagar Medicine Infectious Diseases 617-414-2842
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Investigating the Efficacy and Safety of CVT-301 (Levodopa Inhalation Powder) in Parkinson's Disease Patients With Motor Response Fluctuations (OFF Phenomena) Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
Randomized, Double Blind, Placebo-Controlled Trial of the Safety and Efficacy of HORIZANT� (Gabapentin Enacarbil) Extended-Release Tablets for the Treatment of Alcohol Use Disorder Eric Devine Psychiatry N/A 617-414-2039
Open-Label, Dose-Escalating, Phase I Study to Determine Safety and Pharmacokinetic Parameters of Subcutaneous (SC) VRC01, and VRC01LS, Potent Anti-HIV Neutralizing Monoclonal Antibodies, in HIV-1-Exposed Infants (IMPAACT P1112) Ellen Cooper Pediatrics Pediatric Infectious Diseases 617-414-5813
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Assessing the Effect of Gelesis100 on Body Weight in Overweight and Obese Subjects with and without Type 2 Diabetes GLOW (Gelesis Loss Of Weight) Caroline Apovian Medicine Endocrinology, Diabetes and Nutrition 617-638-5921
VITAL: A Phase 3, Randomized, Multicenter, Double-Blind, Placebo-Controlled, 2-Arm, Efficacy and Safety Study of NEOD001 Plus Standard of Care Versus Placebo Plus Standard of Care in Subjects with Light Chain (AL) Vaishali Sanchorawala Medicine Hematology and Medical Oncology 781-207-7591
NAVIGATE-ESUS: Multicenter, randomized, double-blind, double-dummy, active-comparator, event-driven, superiority phase III study of secondary prevention of stroke and prevention of systemic embolism in patients with a recent Embolic Stroke of Undetermined Source (ESUS), comparing rivaroxaban 15 mg once daily with aspirin 100 mg Viken Babikian Neurology Stroke 617-414-1171
A Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 Delivered by Single or Multi-Dose Intravitreal Injection(s) to Subjects with Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Crandall Peeler Ophthalmology N/A 617-414-8848
Randomized Trial to Prevent Vascular Events in HIV - REPRIEVE (A5332) Nina Lin Medicine Infectious Diseases 617-414-2842
Predicting the Safety and Effectiveness of Inferior Vena Cava Filters (PRESERVE). Jeffrey Kalish Surgery Vascular and Endovascular Surgery 617-414-6832
Prevention of Recurrence of Crohn’s Disease by Fecal Microbiota Therapy (FMT) Francis Farraye Medicine Gastroenterology 617-638-6527
DALF 1016: A Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Two Dose Strengths of Dalfampridine Extended Release Tablets for Treatment of Stable Walking Deficits in Post-Ischemic Stroke Brigid Dwyer Neurology Stroke 617-414-1171
An Open-Label Phase 3b Study to Assess Mucosal Healing in Subjects with Moderately to Severely Active Crohn’s Disease Treated with Vedolizumab IV Effect of Vedolizumab IV on Mucosal Healing in Crohn’s Disease Francis Farraye Medicine Gastroenterology 617-638-6527
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Trial of Oral RPC1063 as Induction and Maintenance Therapy for Moderate to Severe Ulcerative Colitis Francis Farraye Medicine Gastroenterology 617-638-6527
CTSU #EAY131: Molecular Analysis for Therapy Choice (MATCH) Marjory Charlot Cancer Care Center N/A 617-638-8213
A Randomized Phase III Study of Sublobar Resection (SR) versus Stereotactic Ablative Radiotherapy (SAbR) in High Risk Patients with Stage I Non-Small Cell Lung Cancer (NSCLC) Kei Suzuki Surgery Thoracic Surgery 617-414-6832
Alcohol Disorder hosPital Treatment (ADOPT) Study Richard Saitz Medicine General Internal Medicine 617-414-1374
Longitudinal Evaluation of Amyloid Risk and Neurodegeneration the LEARN Study. A companion study to Anti-Amyloid Treatment in Asymptomatic Alzheimers Disease (A4) Trial Robert Stern Neurology N/A 617-638-5670
Standard Versus Negative Pressure Vaccum Dressings (PICO) in Lower-Extremity Bypass Patients (PICO-LEB). Jeffrey Siracuse Surgery Vascular and Endovascular Surgery 617-414-6832
Detection of Early Lung Cancer Among Military Personnel (DECAMP-2): Screening of Patients with Early Stage Lung Cancer of at High Risk for Developing Lung Cancer Avrum Spira Medicine Computational Biomedicine 617-638-8716
A Prospective Observational Study of Adult Strabismus (SAS1) Stephen Christiansen Ophthalmology N/A 617-414-8848
A Phase 2a, Randomized, Double-Blind, Placebo-Controlled 21-Day Treatment Study, Including an fMRI Sub-Study, to Evaluate the Effect of HT-3951 on Upper Extremity Motor Function Following Ischemic Stroke (RESTORE) Courtney Takahashi Neurology Stroke 617-414-1171
A multicenter, randomized, double-blind, placebo-controlled, Phase 2 study evaluating the efficacy and safety of Anifrolumab in adult subjects with active proliferative lupus nephritis Ramon Bonegio Medicine Nephrology 617-414-1968
A Phase 3, Double-Blind, Randomized, Long-Term, Placebo-Controlled, Multicenter Study Evaluating the Safety and Efficacy of Obeticholic Acid in Subjects with Nonalcoholic Steatohepatitis Michelle Long Medicine Gastroenterology 617-638-6527
DOUBLE-BLIND PLACEBO CONTROLLED TRIAL OF THE TREATMENT OF CHRONIC LARYNGITIS WITH AMITRIPTYLINE Pieter Noordzij Otolaryngology - Head and Neck Surgery N/A 617-414-1776
Janssen: Efficacy and Safety of Rivaroxaban Prophylaxis Compared with Placebo in AmbulatoryCancer Patients Initiating Systemic Cancer Therapy and at High Risk for VenousThromboembolism (RIVA) John Sloan Medicine Hematology and Medical Oncology 781-207-7591
Potential pharmacokinetic interaction of human immunodeficiency virus (HIV) antiretroviral agents as fixed-dose combinations and riociguat in HIV patients Elizabeth Klings Pulmonary Center N/A 617-638-4344
TITLE: The efficacy and safety of initial triple versus initial dual oral combination therapy in patients with newly diagnosed pulmonary arterial hypertension: A multi-center, double-blind, placebo-controlled, Phase 3b study Elizabeth Klings Medicine Rheumatology 617-638-4475
merck-A Phase III Study of Pembrolizumab (MK-3475) vs. Chemotherapy in Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Carcinoma (KEYNOTE-177) Kevan Hartshorn Cancer Care Center N/A 617-638-6521
A Phase 2b/3 Randomized, Double-blind, Placebo-Controlled, Parallel Group, Multicenter Study Investigating the Efficacy and Safety of JNJ-54861911 in Subjects who are Asymptomatic At Risk for Developing Alzheimer’s Dementia Robert Stern Neurology N/A 617-638-5670
A Phase 3, Multicenter, Open-Label Extension Trial of Oral RPC1063 as Therapy for Moderate to Severe Ulcerative Colitis Francis Farraye Medicine Gastroenterology 617-638-6527
EA5142: Adjuvant Nivolumab in Resected Lung Cancers (ANVIL) - A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers. Marjory Charlot Medicine Hematology and Medical Oncology 617-638-8213
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter study to investigate the Efficacy and Safety of Mongersen (GED-0301)for the treatment of subjects with active Crohn's Disease Francis Farraye Medicine Medicine 617-638-6527
A double blind, randomized, placebo-controlled trial evaluating efficacy and safety of oral nintedanib, 150 mg twice daily for 52 weeks (with follow up until last patient out up to a maximum of 2 years) in patients with ‘Systemic Sclerosis associated interstitial lung disease’ Robert Simms Arthritis Center N/A 617-414-2507
A PHASE III,MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, ACTIVE-CONTROLLED STUDY COMPARING THE EFFICACY AND SAFETY OF GASTRIC RETENTIVE, CONTROLLED RELEASE ACCORDION PILL™CARBIDOPA/LEVODOPA (AP-CD/LD) TO IMMEDIATE RELEASE CD/LD IN FLUCTUATING PARKINSON’S DISEASE PATIENTS Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
A prospective, randomized, double blind, placebo-controlled, multicenter, Phase 3 efficacy and safety study of OTO-104 given as a single intratympanic injection in subjects with unilateral Meniere’s disease. Kenneth Grundfast Otolaryngology - Head and Neck Surgery N/A 617-414-1756
AN OPEN-LABEL, MULTI-CENTER, FOLLOW-UP STUDY DESIGNED TO EVALUATE THE LONG-TERM EFFECTS OF AP-CD/LD IN FLUCTUATING PARKINSON'S DISEASE SUBJECTS WHO COMPLETED STUDY IN 11 004 Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
A PHASE IIB, MULTICENTER, RANDOMIZED, DOUBLE-BLIND,PLACEBO-CONTROLLED, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF RIVIPANSEL (GMI-1070) IN THE TREATMENT OF VASO-OCCLUSIVE CRISIS IN HOSPITALIZED SUBJECTS WITH SICKLE CELL DISEASE Hedy Smith Medicine Hematology and Medical Oncology 617-414-5729
Dose Finding Study in Central Nervous System (CNS) Magnetic Resonance Imaging (MRI) Osamu Sakai Radiology N/A 617-638-6591
NIDA (National Institute on Drug Abuse) CTN (Clinical Trials Network) Protocol 0064: Assessing Long-term CTN-0049 Outcomes, HCV Prevalence and Progression along the HCV Care Continuum among HIV/HCV Co-infected Substance Users in the U.S. Margaret Sullivan Medicine Infectious Diseases 617-414-1395
SURE-PD3 (Study of URate Elevation in PD, phase 3) - A randomized, double-blind, placebo-controlled trial of urate elevating Inosine treatment to slow clinical decline in early Parkinson’s disease (PD) Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
The safety and efficacy of Macitentan for Treatment of Pulmonary Arterial Hypertension in Sickle Cell Disease Elizabeth Klings Medicine Pulmonary, Allergy and Critical Care 617-353-2087
AdreView™ Myocardial Imaging for Risk Evaluation – A multicentre trial to guide ICD implantation in NYHA class II & III heart failure patients with 30" target="_blank">≤LVEF≤35" target="_blank">. ADMIRE-ICD Robert Helm Medicine Cardiology 617-353-2087
A STUDY OF THE EFFICACY AND SAFETY OF BARDOXOLONE METHYL IN PATIENTS WITH CONNECTIVE TISSUE DISEASE-ASSOCIATED PULMONARY ARTERIAL HYPERTENSION Elizabeth Klings Arthritis Center N/A 617-638-4475
A Phase 2, Placebo Controlled, Randomized, Double-Blind, Parallel-Arm Study to Evaluate Efficacy and Safety of BMS-986141 For the Prevention of Recurrent Brain Infarction in Subjects receiving acetylsalicylic acid (ASA) following Acute Ischemic Stroke or Transient Ischemic Attack Rafael Jose Romero Neurology Stroke 617-414-1171
Women in Control: A Virtual World Study of Diabetes Self-Management (Women in Control 2.0) Suzanne Mitchell Family Medicine N/A 617-414-6207
A011401 - RANDOMIZED PHASE III TRIAL EVALUATING THE ROLE OF WEIGHT LOSS IN ADJUVANT TREATMENT OF OVERWEIGHT AND OBESE WOMEN WITH EARLY BREAST CANCER Lauren Oshry Medicine Hematology and Medical Oncology 617-638-8260
Study Title: SWOG #S1500: A Randomized, Phase II Efficacy Assessment of Multiple MET Kinase Inhibitors (Cabozantinib [NSC #761968], Crizotinib [NSC #749005], Savolitinib [NSC #785348], and Sunitinib [NSC #736511]) in Metastatic Papillary Renal Carcinoma (PAPMET) Gretchen Gignac Cancer Care Center N/A 617-638-8261
A Study to Compare Bone Marrow Transplantation to Standard Care in Adolescents and Young Adults with Severe Sickle Cell Disease Lillian McMahon Medicine General Internal Medicine 617-414-5729
Phase I Safety and Pharmacokinetic Study of Maraviroc in HIV-1-Exposed Infants at Risk of Acquiring HIV-1 Infection (IMPAACT 2007) Ellen Cooper Pediatrics Pediatric Infectious Diseases 617-414-5813
Protocol I8D-MC-AZET A Randomized, Double-Blind, Placebo-Controlled and Delayed-Start Study of LY3314814 in Mild Alzheimer’s Disease Dementia (The DAYBREAK Study) Robert Stern Neurology N/A 617-638-5670
Evaluation of medium chain triglycerides in a mixed racial population of patients with metabolic syndrome: a feasibility study Caroline Apovian Medicine Endocrinology, Diabetes and Nutrition 617-638-5921
A Multicenter Assessment of a Spontaneous Preterm Birth Risk Predictor (treetoP) Glenn Markenson Obstetrics / Gynecology Maternal-Fetal Medicine 617-414-5176
An open label, multi-center study evaluating the imaging characteristics of a follow-up 18F-AV-1451 scan in subjects that participated in the confirmatory cohort of the 18F-AV-1451-A05 study Robert Stern Neurology N/A 617-638-5368
The DIAGNOSE CTE Research Project Robert Stern Neurology N/A 617-414-8389
A Randomized Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia (ITX5) Stephen Christiansen Ophthalmology N/A 617-414-8848
A Phase 1 Study of the Safety and Tolerability of a Single Dose Administration of CVT-301 (Levodopa Inhalation Powder) when administered for Early Morning Off Symptoms in Patients with Parkinson's Disease Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
Merck 355: A Randomized, Double-Blind, Phase III Study of Pembrolizumab (MK-3475) plus Chemotherapy vs Placebo plus Chemotherapy for Previously Untreated Locally Recurrent Inoperable or Metastatic Triple Negative Breast Cancer - (KEYNOTE-355) Lauren Oshry Cancer Care Center N/A 617-638-6521
“MultiPoint Pacing™ Post Market Study (MPP PMS)” Kevin Monahan Medicine Cardiology 617-353-2087
Impact of Smoking and its Cessation on Systemic and Airway Immune Activation Nina Lin Medicine Infectious Diseases 617-414-2842
A021501 - Preoperative Extended Chemotherapy Vs. Chemotherapy Plus Hypofractioned Radiation Therapy for Borderline Resectable Adenocarcinoma of the Head of the Pancreas Kevan Hartshorn Medicine Hematology and Medical Oncology 617-638-8213
A Phase I-II Trial of Daratumumab for the treatment of patients with AL amyloidosis Vaishali Sanchorawala Cancer Care Center N/A 781-207-7591
S1605 - Atezolizumab in Treating Patients With Recurrent BCG-Unresponsive Non-muscle Invasive Bladder Cancer Gretchen Gignac Medicine Hematology and Medical Oncology 617-638-8213
Alzheimer’s Disease Neuroimaging Initiative 3 (ADNI3) Ronald Killiany Neurology N/A 617-638-5670
PIONEER 2 – vs. SGLT-2 Inhibitor Efficacy and Safety of Oral Semaglutide versus Empagliflozin in Subjects with Type 2 Diabetes Mellitus Devin Steenkamp Medicine Endocrinology, Diabetes and Nutrition 617-414-5729
A prospective, randomized, international, multicenter, double-arm, controlled, open-label study of Riociguat in patients with pulmonary arterial hypertension (PAH) who are on a stable dose of phosphodiesterase-5 inhibitors (PDE-5i) with or without endothelin receptor antagonist (ERA), but not at treatment goal Elizabeth Klings Arthritis Center N/A 617-353-2087
A Phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of GDC-0853 in patients with moderate to severe active systemic lupus erythematosus Ramon Bonegio Medicine Nephrology 617-414-1968
Registry of Amyloid Positive Patients for Alzheimer’s Disease Drug Research Trials (RAmP) Robert Stern Neurology N/A 617-414-1196
Efficacy and safety of SAR156597 in the treatment of diffuse cutaneous Systemic Sclerosis (dcSSc): A randomized, double-blind, placebo-controlled, 24-week, proof of concept study Robert Simms Arthritis Center N/A 617-414-2507
ARAMIS-A randomized multicenter study for isolated skin vasculitis Paul Monach Medicine Rheumatology 617-638-5383
SINGLE ARM STUDY OF ALXN1210 IN COMPLEMENT INHIBITOR TREATMENT-NAÏVE ADULT AND ADOLESCENT PATIENTS WITH ATYPICAL HEMOLYTIC UREMIC SYNDROME (aHUS) Jean Francis Medicine Nephrology 617-414-1968
S1418 - A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer with >/= 1 CM Residual Invasive Cancer or Positive Lymph Nodes (ypN+) after Neoadjuvant Chemotherapy Lauren Oshry Medicine Hematology and Medical Oncology 617-638-8213
A PHASE 1 MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-ESCALATION STUDY OF VONAPANITASE ADMINISTERED FOLLOWING ANGIOPLASTY OF A DISTAL POPLITEAL, TIBIAL OR PERONEAL ARTERY IN PATIENTS WITH PERIPHERAL ARTERY DISEASE Jeffrey Siracuse Surgery Vascular and Endovascular Surgery 617-638-8622
Evaluation of the impact of Point of Care Liat Influenza A/B Testing in the Emergency Department at Boston Medical Center Elissa Perkins Emergency Medicine N/A 617-414-4622
Amblyopia Treatment Study: Binocular Dig Rush Game Treatment for Amblyopia (ATS20) Stephen Christiansen Ophthalmology N/A 617-414-8848
Multi-center, open-label, uncontrolled study to assess contraceptive efficacy and safety of Mirena during extended use beyond 5 years in women 18 to 35 years of age including a subgroup evaluation of treatment effect on heavy menstrual bleeding Katharine White Obstetrics / Gynecology General Gynecology 412-576-8598
Evomela - A Phase II Single-Center, Open-Label, Safety and Efficacy Study of Propylene Glycol-Free Melphalan Hydrochloride (Evomela) in AL Amyloidosis Patients Undergoing Autologous Stem Cell Transplantation Shayna Sarosiek Cancer Care Center N/A 617-638-8274
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 3 STUDY TO EVALUATE THE SAFETY AND EFFICACY OF CCX168 (ACACOPAN) IN PATIENTS WITH ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA)-ASSOCIATED VASCULITIS TREATED CONCOMITANTLY WITH RITUXIMAB OR CYCLOPHOSPHAMIDE/AZATHIOPRINE Paul Monach Medicine Rheumatology 617-353-2087
Impact of fever prevention in brain injured patients (INTREPID) Anna Cervantes-Arslanian Neurology Stroke 617-414-1171
CUTIS-Clinical transcriptomics in systemic vasculitis Christina Lam Medicine Rheumatology 617-638-5383
PROSPECTIVE, MULTI‐CENTER, RANDOMIZED CONTROLLED TRIAL EVALUATING THE USE OF PRIMATRIX DERMAL REPAIR SCAFFOLD FOR THE MANAGEMENT OF DIABETIC FOOT ULCERS. Hau Pham Surgery Podiatry 617-638-8622
An Open-Label Study Assessing the Effect of Gelesis100 on Weight Loss and Weight Maintenance in Overweight and Obese Subjects who Completed the GLOW Study (G-04) Caroline Apovian Medicine Endocrinology, Diabetes and Nutrition 617-638-5921
A Randomized, Controlled Double-blind Study Comparing the Efficacy and Safety of Orelvo (voclosporin) (23.7 mg Twice Daily) with Placebo in Achieving Renal Response in Subjects with Active Lupus Nephritis Ramon Bonegio Medicine Nephrology 617-414-1968
A Phase 3, Double-blind, Randomized, Placebo-controlled, Multicenter Study of GBT440 Administered Orally to Patients with Sickle Cell Disease Lillian McMahon Medicine General Internal Medicine 617-414-5729
A multi-centre, randomized, double-blind (sponsor open), placebocontrolled, repeat-dose, proof of mechanism study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and explore efficacy of GSK2330811 in participants with diffuse cutaneous systemic sclerosis. Robert Simms Medicine Rheumatology 617-414-2507
EA8143: A Phase 3 Randomized Study Comparing Perioperative Nivolumab vs. Observation in Patients with Localized Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC) Gretchen Gignac Medicine Hematology and Medical Oncology 617-638-8213
Immunogenicity of Influenza, Pneumococcal, and Hepatitis B vaccines in Inflammatory Bowel Disease patients treated with Vedolizumab Sharmeel Wasan Medicine Gastroenterology 617-638-6527
Randomized Trial Comparing the Boston Scientific RANGER™ Paclitaxel Coated Balloon vs Standard Balloon Angioplasty for the Treatment of Superficial Femoral Arteries (SFA) and Proximal Popliteal Arteries (PPA) Alik Farber Surgery Vascular and Endovascular Surgery 617-414-6832
Mind Your Walk Intervention for Community-based Management of Knee OA: A Feasibility Study Deepak Kumar Radiology N/A 617-358-3125
An Open-Label, Multicenter Study to Evaluate the Pharmacokinetics, Safety, and Efficacy of Glecaprevir/Pibrentasvir in Pediatric Subjects with Genotypes 1-6 Chronic Hepatitis C Virus (HCV) Infection (AbbVie M16-123) Vishaka Sabharwal Pediatrics Pediatric Infectious Diseases 617-414-5813
AN EXTENDED ACCESS PROGRAM TO ASSESS LONG-TERM SAFETY OF BARDOXOLONE METHYL IN PATIENTS WITH PULMONARY HYPERTENSION Elizabeth Klings Medicine Rheumatology 617-638-4475
GU002 - PHASE II-III TRIAL OF ADJUVANT RADIOTHERAPY AND ANDROGEN DEPRIVATION FOLLOWING RADICAL PROSTATECTOMY WITH OR WITHOUT ADJUVANT DOCETAXEL Gretchen Gignac Medicine Hematology and Medical Oncology 617-638-8213
A Randomized, Prospective, Multi-Center Feasibility Study of APT001 Plasma/Nitric Oxide Therapy for the Treatment of Diabetic Foot Ulcers Hau Pham Surgery Podiatry 617-638-8622
A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of CX-8998 for Essential Tremor Okeanis Vaou Neurology N/A 617-638-7747
A Phase 3, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Switching from a Regimen of Dolutegravir and Either Emtricitabine/Tenofovir Alafenamide or Emtricitabine/Tenofovir Disoproxil Fumarate to a Fixed Dose Combination of Bictegravir/Emtricitabine/Tenofovir Alafenamide in HIV-1 Infected Subjects who are Virologically Suppressed Nina Lin Medicine Infectious Diseases 617-414-2842
Parallel-Group, Placebo-Controlled Randomized Study Investigating the Effect of Intravenous Iso-osmolar Iodinated Contrast Material Iodixanol (Visipaque Injection 320 mgI/mL) on Renal Function in Adults with Chronic Kidney Disease (CKD) Stage III or Stage IV Who Have Undergone Endovascular Aneurysm Repair (EVAR) Jeffrey Siracuse Surgery Vascular and Endovascular Surgery 617-414-6832
A multi-center, single-blind, randomized clinical trial to compare two copper IUDs: Mona Lisa NT Cu380 Mini and ParaGard Katharine White Obstetrics / Gynecology General Gynecology 412-576-8598
A Phase 1 Open-Label, Dose-Escalation Study to Evaluate Safety, Pharmacokinetic, and Biological Activity of INCB059872 in Subjects With Sickle Cell Disease Elizabeth Klings Medicine Hematology and Medical Oncology 617-414-5729
Zoster Eye Disease Study: A multi-center, randomized, double-masked, placebo-controlled clinical trial of suppressive valacyclovir for one year in immunocompetent study participants with an episode of dendriform epithelial keratitis, stromal keratitis, endothelial keratitis, and/or iritis due to Herpes Zoster Ophthalmicus (HZO) in the year prior to enrollment. (ZEDS) Hyunjoo Lee Ophthalmology N/A 617-414-8848
NRG-LU002 - Maintenance Systemic Therapy Versus Consolidative Stereotactic Body Radiation Therapy (SBRT) Plus Maintenance Systemic Therapy For Limited Metastatic Non-Small Cell Lung Cancer (NSCLC): A Randomized Phase II/III Trial Marjory Charlot Medicine Hematology and Medical Oncology 617-638-8213
Safety and Immunogenicity of Adjuvanted versus High-Dose Inactivated Influenza Vaccines in Older Adults (Centers for Disease Control & Prevention Clinical Immunization Safety Assessment (CISA) Project) Elizabeth Barnett Pediatrics Pediatric Infectious Diseases 617-414-5885
Janssen 54767414AMY3001: A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of Daratumumab in Combination with Cyclophosphamide, Bortezomib and Dexamethasone (CyBorD) Compared With CyBorD Alone in Newly Diagnosed Systemic AL Amyloidosis Vaishali Sanchorawala Cancer Care Center N/A 781-207-7591
A Phase 4 Study to Assess the Safety and Immunogenicity of VAXCHORA (Cholera Vaccine, Live, Oral) in Children 2 to Elizabeth Barnett Pediatrics Pediatric Infectious Diseases 617-414-5885
Evaluation of Brentuximab Vedotin for Diffuse Cutaneous Systemic Sclerosis: A Phase 1/2 Multicenter Randomized, Double Blinded, Safety Study Robert Simms Medicine Rheumatology 617-638-5383
A phase II randomised, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of orally administered BI 409306 during a 52-week treatment period as an early intervention in patients with attenuated psychosis syndrome. David Henderson Psychiatry N/A 617-414-1904
A multi-center prospective study to evaluate the safety and effectiveness of the VasQ external support for arteriovenous fistula. Alik Farber Surgery Vascular and Endovascular Surgery 617-414-6839
A031501 - PHASE III RANDOMIZED ADJUVANT STUDY OF MK-3475 (PEMBROLIZUMAB) IN MUSCLE INVASIVE AND LOCALLY ADVANCED UROTHELIAL CARCINOMA (AMBASSADOR) VERSUS OBSERVATION Gretchen Gignac Medicine Hematology and Medical Oncology 617-638-8213
A single-center, randomized, double-blind, double-dummy, parallel-group study comparing oral sedation to intravenous sedation for ocular procedures. Manju Subramanian Ophthalmology N/A 617-414-8848
NRG-HN004: Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Stage III-IVB Head and Neck Cancer with a Contraindication to Cisplatin: Safety Lead-In Portion Minh-Tam Truong Medicine Hematology and Medical Oncology 617-638-8213
NRG GU003 - A RANDOMIZED PHASE III TRIAL OF HYPOFRACTIONATED POST-PROSTATECTOMY RADIATION THERAPY (HYPORT) VERSUS CONVENTIONAL POST-PROSTATECTOMY RADIATION THERAPY (COPORT) Ariel Hirsch Radiation Oncology N/A 617-638-8213
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Subjects with Parkinson’s Disease Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
A Phase 3 Twelve-week Multi-Center Multinational Randomized Double-Blind Double-Dummy Parallel Group Study to Determine the Efficacy Safety and Tolerability of P2B001 Once Daily Compared to its Individual Components in Subjects With Early Parkinson’s Disease and to a Calibration Arm of Pramipexole ER Marie-Helene Saint-Hilaire Neurology N/A 617-638-7747
A Randomized, Multi-center, Double-Blind, Parallel-Group Clinical Study Comparing the Efficacy and Safety of MYL-1501D Produced by Two Manufacturing Processes in Type 1 Diabetes Mellitus Patients Devin Steenkamp Medicine Endocrinology, Diabetes and Nutrition 617-638-5921