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Participate in Research or Clinical Trials

For general information about participating in research, see http://www.bumc.bu.edu/ohra/for-research-participants/ and https://www.bmc.org/research-operations/participate-research.

If you have any questions or do not see the study you are interested in, please contact the Clinical Trial Office at [email protected]

Project Title Link Principal Investigator Department Section E-mail Phone
AMITRIPTYLINE STUDY REVISED Pieter Noordzij Otolaryngology - Head and Neck Surgery N/A 617-414-1776
Porche Gintas Krisciunas Otolaryngology - Head and Neck Surgery N/A 617-414-1776
A phase II randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of orally administered BI 409306 during a 52-week treatment period as an early intervention in patients with attenuated psychosis syndrome. David Henderson Psychiatry N/A 617-414-1904
Mona Lisa Katharine White Obstetrics / Gynecology General Gynecology 617-383-3500
SWOG #S1320 Adam Lerner Medicine Hematology and Medical Oncology 617-638-8213
EA5142: Adjuvant Nivolumab in Resected Lung Cancers (ANVIL) - A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers. Marjory Charlot Medicine Hematology and Medical Oncology 617-638-8213
A021501 - Preoperative Extended Chemotherapy Vs. Chemotherapy Plus Hypofractioned Radiation Therapy for Borderline Resectable Adenocarcinoma of the Head of the Pancreas Kevan Hartshorn Medicine Hematology and Medical Oncology 617-638-8213
S1605 - Atezolizumab in Treating Patients With Recurrent BCG-Unresponsive Non-muscle Invasive Bladder Cancer Gretchen Gignac Medicine Hematology and Medical Oncology 617-638-8213
S1418 - A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer with >/= 1 CM Residual Invasive Cancer or Positive Lymph Nodes (ypN+) after Neoadjuvant Chemotherapy Lauren Oshry Medicine Hematology and Medical Oncology 617-638-8213
EA8143: A Phase 3 Randomized Study Comparing Perioperative Nivolumab vs. Observation in Patients with Localized Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC) Gretchen Gignac Medicine Hematology and Medical Oncology 617-638-8213
GU002 - PHASE II-III TRIAL OF ADJUVANT RADIOTHERAPY AND ANDROGEN DEPRIVATION FOLLOWING RADICAL PROSTATECTOMY WITH OR WITHOUT ADJUVANT DOCETAXEL Gretchen Gignac Medicine Hematology and Medical Oncology 617-638-8213
RACE: Randomized controlled trial of Autologous microbiome reconstitution to prevent Colonization… Christine Liu Medicine Geriatrics 617-638-6109
NRG-LU002 - Maintenance Systemic Therapy Versus Consolidative Stereotactic Body Radiation Therapy (SBRT) Plus Maintenance Systemic Therapy For Limited Metastatic Non-Small Cell Lung Cancer (NSCLC): A Randomized Phase II/III Trial Marjory Charlot Medicine Hematology and Medical Oncology 617-638-8213
A031501 - PHASE III RANDOMIZED ADJUVANT STUDY OF MK-3475 (PEMBROLIZUMAB) IN MUSCLE INVASIVE AND LOCALLY ADVANCED UROTHELIAL CARCINOMA (AMBASSADOR) VERSUS OBSERVATION Gretchen Gignac Medicine Hematology and Medical Oncology 617-638-8213
NRG-HN004: Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Stage III-IVB Head and Neck Cancer with a Contraindication to Cisplatin: Safety Lead-In Portion Minh-Tam Truong Medicine Hematology and Medical Oncology 617-638-8213
NRG GU003 - A RANDOMIZED PHASE III TRIAL OF HYPOFRACTIONATED POST-PROSTATECTOMY RADIATION THERAPY (HYPORT) VERSUS CONVENTIONAL POST-PROSTATECTOMY RADIATION THERAPY (COPORT) Ariel Hirsch Radiation Oncology N/A 617-638-8213
Pfizer Rivipansel Hedy Smith Medicine Hematology and Medical Oncology 617-414-5729
A Study to Compare Bone Marrow Transplantation to Standard Care in Adolescents and Young Adults with Severe Sickle Cell Disease Lillian McMahon Medicine General Internal Medicine 617-414-5729
PIONEER 2 – vs. SGLT-2 Inhibitor Devin Steenkamp Medicine Endocrinology, Diabetes and Nutrition 617-414-5729
GBT440 Lillian McMahon Medicine General Internal Medicine 617-414-5729
Anifrolumab Ramon Bonegio Medicine Nephrology 617-414-1968
Genentech GA30044 Ramon Bonegio Medicine Nephrology 617-414-1968
Btk inhibitor LTE Ramon Bonegio Medicine Nephrology 617-414-1968
AURORA Ramon Bonegio Medicine Nephrology 617-414-1968
Tafamidis Meglumine John Berk Medicine Amyloid Research & Training Program 617-638-4591
Evomela Shayna Sarosiek Cancer Care Center N/A 617-638-8274
XC-8998 for Essential Tremor Okeanis Vaou Neurology N/A 617-638-7747
P2B Marie-Helene Saint-Hilaire Neurology N/A 617-638-7747
Protocol H8A-MC-LZAZ Robert Stern Alzheimers Disease Center N/A 617-414-1196
Registry of Amyloid Positive Patients for Alzheimer’s Disease Drug Research Trials (RAmP) Robert Stern Neurology N/A 617-414-1196
PHARMACOKINETIC PROPERTIES OF ANTIRETROVIRAL AND RELATED DRUGS DURING PREGNANCY AND POSTPARTUM (IMPAACT P1026S) Mark Mirochnick Pediatrics Pediatric Infectious Diseases 617-414-5813
Open-Label, Dose-Escalating, Phase I Study to Determine Safety and Pharmacokinetic Parameters of Subcutaneous (SC) VRC01, and VRC01LS, Potent Anti-HIV Neutralizing Monoclonal Antibodies, in HIV-1-Exposed Infants (IMPAACT P1112) Ellen Cooper Pediatrics Pediatric Infectious Diseases 617-414-5813
Phase I Safety and Pharmacokinetic Study of Maraviroc in HIV-1-Exposed Infants at Risk of Acquiring HIV-1 Infection (IMPAACT 2007) Ellen Cooper Pediatrics Pediatric Infectious Diseases 617-414-5813
Randomized Phase I Study of the Infectivity, Safety, and Immunogenicity of a Single Dose of the Recombinant Live-Attenuated Respiratory Syncytial Virus (RSV) Vaccines RSV deltaNS2/delta1313/I1314L or RSV 276 or Placebo, Delivered as Nose Drops to RSV-Seronegative Infants 6 to 24 Months of Age (IMPAACT 2018) Ellen Cooper Pediatrics Pediatric Infectious Diseases 617-414-5813
PHASE I/II, MULTI-CENTER, OPEN-LABEL PHARMACOKINETIC, SAFETY, TOLERABILITY AND ANTIVIRAL ACTIVITY OF GSK1349572, A NOVEL INTEGRASE INHIBITOR, IN COMBINATION REGIMENS IN HIV-1 INFECTED INFANTS, CHILDREN AND ADOLESCENTS (IMPAACT P1093) Stephen Pelton Pediatrics Pediatric Infectious Diseases 617-414-5813
ISCHEMIA Claudia Hochberg Medicine Cardiology 617-638-8716
Absorb™ BVS Alice Jacobs Medicine Cardiology 617-638-8716
Decamp 2 Avrum Spira Medicine Computational Biomedicine 617-638-8716
Improving Outcomes in Neonatal Abstinence Syndrome (NAS) Michael Silverstein Pediatrics Pediatric General 617-414-3827
Efficacy and safety of SAR156597 in the treatment of diffuse cutaneous Systemic Sclerosis (dcSSc): A randomized, double-blind, placebo-controlled, 24-week, proof of concept study Robert Simms Arthritis Center N/A 617-414-2507
GSK, 201247 Robert Simms Medicine Rheumatology 617-414-2507
Rituximab Robert Simms Medicine Pulmonary, Allergy and Critical Care 617-414-2507
CTN-0049 Outcomes, HCV Margaret Sullivan Medicine Infectious Diseases 617-414-1395
ANCHOR Elizabeth Stier Obstetrics / Gynecology General Gynecology 323-875-0267
An open label, multicenter study evaluating the Safety and Imaging Characteristics of a new PET Scan Test in Healthy Volunteers, Subjects with Mild Cognitive Impairment and Subjects with Alzheimer's Disease Dementia Robert Stern Alzheimers Disease Center N/A 617-638-5368
Follow-up Avid PET Scan Study Robert Stern Neurology N/A 617-638-5368
RTOG #R0534: A Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPPORT) in Prostate Cancer Patients with a Rising PSA After Radical Prostatectomy Ariel Hirsch Radiation Oncology N/A 617-638-8260
RTOG #R0920: A PHASE III STUDY OF POSTOPERATIVE RADIATION THERAPY (IMRT) +/- CETUXIMAB FOR LOCALLY-ADVANCED RESECTED HEAD AND NECK CANCER Minh-Tam Truong Radiation Oncology N/A 617-638-8260
FEASIBILITY/OUTCOMES STUDY OF HYPOFRACTIONATED STEREOTACTIC BODY RADIATION THERAPY AS A BOOST TO THE PROSTATE FOR TREATMENT OF LOCALIZED, NON-METASTATIC, HIGH RISK PROSTATE CANCER Ariel Hirsch Radiation Oncology N/A 617-638-8260
Dexamethasone Plus MLN9708 Vaishali Sanchorawala Medicine Hematology and Medical Oncology 617-638-8260
CTSU #E1412: Randomized Phase II Open Label Study of Lenalidomide R-CHOP (R2CHOP) vs RCHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone) in Patients with Newly Diagnosed Diffuse Large B Cell Lymphoma John Sloan Medicine Hematology and Medical Oncology 617-638-8260
A011401 - RANDOMIZED PHASE III TRIAL EVALUATING THE ROLE OF WEIGHT LOSS IN ADJUVANT TREATMENT OF OVERWEIGHT AND OBESE WOMEN WITH EARLY BREAST CANCER Lauren Oshry Medicine Hematology and Medical Oncology 617-638-8260
Riociguat in HIV patients Elizabeth Klings Pulmonary Center N/A 617-638-4344
Mind your Walk - Knee OA Deepak Kumar Radiology N/A 617-358-3125
OTO-104 Kenneth Grundfast Otolaryngology - Head and Neck Surgery N/A 617-414-1756
A Prospective Randomized Trial to Assess PO versus IV Antibiotics for the Treatment of Early Post-op Wound Infection after Extremity Fractures Paul Tornetta Orthopaedic Surgery Orthopaedic Surgery 617-414-6295
Pain - Orthopedic Trauma Paul Tornetta Orthopaedic Surgery Orthopaedic Surgery 617-414-6295
OXYGEN Paul Tornetta Orthopaedic Surgery Orthopaedic Surgery 617-414-6295
I.M.P.R.E.S.S Paul Tornetta Orthopaedic Surgery Orthopaedic Surgery 617-414-6295
MaRISS Rafael Jose Romero Neurology Stroke 617-414-1171
BMS-986141 Rafael Jose Romero Neurology Stroke 617-414-1171
NAVIGATE-ESUS Viken Babikian Neurology Stroke 617-414-1171
DALF 1016: A Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Two Dose Strengths of Dalfampridine Extended Release Tablets for Treatment of Stable Walking Deficits in Post-Ischemic Stroke Brigid Dwyer Neurology Stroke 617-414-1171
HT-3951-201/PXL222158 Courtney Takahashi Neurology Stroke 617-414-1171
INTREPID Anna Cervantes-Arslanian Neurology Stroke 617-414-1171
WIC2 Suzanne Mitchell Family Medicine N/A 617-414-6207
The LEARN Study Robert Stern Neurology N/A 617-638-5670
Early Study Robert Stern Neurology N/A 617-638-5670
Daybreak Robert Stern Neurology N/A 617-638-5670
ADNI-3 Ronald Killiany Neurology N/A 617-638-5670
A Phase II Multi-Center Study of High-Dose Cyclophosphamide and Antithymocyte Globulin Followed by Autologous Hematopoietic Cell Transplantation with Post Transplant Maintenance for the Treatment of Systemic Sclerosis Robert Simms Medicine Rheumatology 617-638-4475
Triton Study Elizabeth Klings Medicine Rheumatology 617-638-4475
RANGER STudy Elizabeth Klings Medicine Rheumatology 617-638-4475
Theravance 0112 Manish Sagar Medicine Infectious Diseases 617-414-2842
REPRIEVE Nina Lin Medicine Infectious Diseases 617-414-2842
Smoking Cessation Nina Lin Medicine Infectious Diseases 617-414-2842
Gilead 380-4030 Nina Lin Medicine Infectious Diseases 617-414-2842
Safety and Immunogenicity of Adjuvanted versus High-Dose Inactivated Influenza Vaccines in Older Adults (Centers for Disease Control & Prevention Clinical Immunization Safety Assessment (CISA) Project) Elizabeth Barnett Pediatrics Pediatric Infectious Diseases 617-414-7225
PaxVax VAXCHORA Elizabeth Barnett Pediatrics Pediatric Infectious Diseases 617-414-5885
NAION Crandall Peeler Ophthalmology N/A 617-414-8848
SAS1 Stephen Christiansen Ophthalmology N/A 617-414-8848
IXT5 Stephen Christiansen Ophthalmology N/A 617-414-8848
Zoster Eye Disease Study: A multi-center, randomized, double-masked, placebo-controlled clinical trial of suppressive valacyclovir for one year in immunocompetent study participants with an episode of dendriform epithelial keratitis, stromal keratitis, endothelial keratitis, and/or iritis due to Herpes Zoster Ophthalmicus (HZO) in the year prior to enrollment. (ZEDS) Hyunjoo Lee Ophthalmology N/A 617-414-8848
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Assessing the Effect of Gelesis100 on Body Weight in Overweight and Obese Subjects with and without Type 2 Diabetes GLOW (Gelesis Loss Of Weight) Caroline Apovian Medicine Endocrinology, Diabetes and Nutrition 617-638-5921
Evaluation of medium chain triglycerides in a mixed racial population of patients with metabolic syndrome: a feasibility study Caroline Apovian Medicine Endocrinology, Diabetes and Nutrition 617-638-5921
GLOW-EX Caroline Apovian Medicine Endocrinology, Diabetes and Nutrition 617-638-5921
Mylan T1D Study Devin Steenkamp Medicine Endocrinology, Diabetes and Nutrition 617-638-5921
Imaging Dementia¿Evidence for Amyloid Scanning (IDEAS) Study: A Coverage with Evidence Development Longitudinal Cohort Study Medicine Amyloid Research & Training Program 617-638-6591
AMC #085: A Pilot Trial of AVD and Brentuximab Vedotin (SGN-35) in the treatment of stage II-IV HIV-associated Hodgkin Lymphoma Mark Sloan Medicine Hematology and Medical Oncology 617-638-8213
NRG #HN001 Minh-Tam Truong Medicine Hematology and Medical Oncology 617-638-8213
Primatrix Hau Pham Surgery Podiatry 617-638-8622
ORI-16-003 Hau Pham Surgery Podiatry 617-638-8622
Abatacept (CTLA4-Ig) for the Treatment of Relapsing, Non-Severe, Granulomatosis with Polyangiitis (Wegener's) (ABROGATE) Paul Monach Medicine Rheumatology 617-414-2512
Effi and Safety of NEOD001 Vaishali Sanchorawala Medicine Hematology and Medical Oncology 781-207-7591
Dara 2002 - A Phase I-II Trial of Daratumumab for the treatment of patients with AL amyloidosis Vaishali Sanchorawala Cancer Care Center N/A 781-207-7591
Janssen 54767414AMY3001: A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of Daratumumab in Combination with Cyclophosphamide, Bortezomib and Dexamethasone (CyBorD) Compared With CyBorD Alone in Newly Diagnosed Systemic AL Amyloidosis Vaishali Sanchorawala Cancer Care Center N/A 781-207-7591
VasQ arteriovenous fistula Alik Farber Surgery Vascular and Endovascular Surgery 617-414-6839
Macitentan Elizabeth Klings Medicine Pulmonary, Allergy and Critical Care 617-353-2087
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 3 STUDY TO EVALUATE THE SAFETY AND EFFICACY OF CCX168 (ACACOPAN) IN PATIENTS WITH ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA)-ASSOCIATED VASCULITIS TREATED CONCOMITANTLY WITH RITUXIMAB OR CYCLOPHOSPHAMIDE/AZATHIOPRINE Paul Monach Medicine Rheumatology 617-353-2087
AdreView™ Myocardial Imaging for Risk Evaluation – A multicentre trial to guide ICD implantation in NYHA class II & III heart failure patients with 30" target="_blank">≤LVEF≤35" target="_blank">. ADMIRE-ICD Robert Helm Medicine Cardiology 617-353-2087
Pembrolizumab (MK-3475) Kevan Hartshorn Cancer Care Center N/A 617-638-6521
Parkinson's Progression Markers Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
CVT-301 Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
Intec DD Study Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
Intec OLE Study Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
SURE-PD3 Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Subjects with Parkinson’s Disease Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
SWOG #S1207: Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk, Hormone Receptor-Positive and HER2/neu Negative Breast Cancer Lauren Oshry Cancer Care Center N/A 617-638-8261
NRG #BN001: Randomized Phase II Trial of Hypofractionated Dose-Escalated Photon IMRT or Proton Beam Therapy versus Conventional Photon Irradiation with Concomitant and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma Minh-Tam Truong Cancer Care Center N/A 617-638-8261
Study Title: SWOG #S1500: A Randomized, Phase II Efficacy Assessment of Multiple MET Kinase Inhibitors (Cabozantinib [NSC #761968], Crizotinib [NSC #749005], Savolitinib [NSC #785348], and Sunitinib [NSC #736511]) in Metastatic Papillary Renal Carcinoma (PAPMET) Gretchen Gignac Cancer Care Center N/A 617-638-8261
The DIAGNOSE CTE Research Project Robert Stern Neurology N/A 617-414-8389
Vedolizumab IV Crohn's Francis Farraye Medicine Gastroenterology 617-638-6527
Fecal Microbiota Therapy (FMT) Francis Farraye Medicine Gastroenterology 617-638-6527
Oral RPC1063 Francis Farraye Medicine Gastroenterology 617-638-6527
The Regenerate Study 747-303 Michelle Long Medicine Gastroenterology 617-638-6527
Oral RPC1063 Francis Farraye Medicine Gastroenterology 617-638-6527
GED-0301 Francis Farraye Medicine Medicine 617-638-6527
Alcohol Disorder hosPital Treatment (ADOPT) Study Richard Saitz Medicine General Internal Medicine 617-414-1374
Janssen: Efficacy and Safety of Rivaroxaban Prophylaxis Compared with Placebo in Ambulatory Cancer Patients Initiating Systemic Cancer Therapy and at High Risk for Venous Thromboembolism (RIVA) John Sloan Medicine Hematology and Medical Oncology 617-638-4178
Best Endovasc vs Best Surg Thera Jeffrey Kalish Surgery Vascular and Endovascular Surgery 617-414-6832
The Impact of Diabetes on REvascularization in BEST-CLI (TIDE) Jeffrey Kalish Surgery Vascular and Endovascular Surgery 617-414-6832
PRESERVE Jeffrey Kalish Surgery Vascular and Endovascular Surgery 617-414-6832
Study of SR vs SAbR in NSCLC Kei Suzuki Surgery Thoracic Surgery 617-414-6832
PICO- Lower Extremity Bypass Jeffrey Siracuse Surgery Vascular and Endovascular Surgery 617-414-6832
Ranger Alik Farber Surgery Vascular and Endovascular Surgery 617-414-6832
Iodixanol Jeffrey Siracuse Surgery Vascular and Endovascular Surgery 617-414-6832
ARAMIS-A randomized multicenter study for isolated skin vasculitis Paul Monach Medicine Rheumatology 617-638-5383
CUTIS-Clinical transcriptomics in systemic vasculitis Christina Lam Medicine Rheumatology 617-638-5383
BRAVOS Robert Simms Medicine Rheumatology 617-638-5383
Hep C Virus in Pregnancy Stephen Pelton Pediatrics Pediatric Infectious Diseases 617-414-5813
Randomized, Double Blind, Placebo-Controlled Trial of the Safety and Efficacy of HORIZANT� (Gabapentin Enacarbil) Extended-Release Tablets for the Treatment of Alcohol Use Disorder Eric Devine Psychiatry N/A 617-414-2039
MirenaE Katharine White Obstetrics / Gynecology General Gynecology 617-383-3500