In May 2020, the Department of Pediatrics was awarded a three-year grant from The JPB Foundation. Together, Children’s HealthWatch and the Center for the Urban Child and Healthy Family are implementing a three-pronged approach—coordinating across research, practice innovation and community narrative building—to support families’ ability to thrive. Children’s HealthWatch is developing and testing new methodologies to understand how structural racism and inequity in early life leads to toxic stress and adversity in health. The Center is accelerating the pilot testing of the Practice of the Future and is preparing for the model’s scaling, both within Boston and around the country. Collectively, both groups are working with Vital Village Network on co-creating a Participatory Action Research Process with a community site for collective research that informs the science and practice of thriving, dismantles policies and structures that perpetrate racism and inequity, and acknowledges values and strengths in communities.