Chronic limb-threatening ischemia is a serious condition where blood flow to the arms or legs is blocked. It can happen when peripheral artery disease becomes severe. 

Symptoms

Symptoms of chronic limb-threatening ischemia include:

  • Intense foot, leg, or arm pain
  • Cold legs, feet, or hands
  • Numbness in your feet, legs, or arms
  • Thicker than usual toenails
  • Shiny and smooth skin on your limbs
  • Sores or skin ulcers that don't heal
  • Skin color changes on your legs, feet, or hands

Treatments

If not treated right away, chronic limb-threatening ischemia can lead to serious complications, including amputation and death. However, it can be treated with:

  • Medications to prevent blood clots
  • Medications to lower blood pressure and/or cholesterol
  • Stents
  • Atherectomy, which is a procedure to remove plaque buildup
  • Surgery to replace an artery

If these treatments don't help bring back blood flow, you may need to have part of your hand, foot, or leg amputated.

Risk Factors

Peripheral artery disease is the cause of this condition. However, there are other factors that raise your risk of developing chronic limb-threatening ischemia, including:

  • Your age
  • Smoking
  • Chronic kidney disease
  • High blood pressure
  • Diabetes
  • High cholesterol

Departments and Programs Who Treat This Condition

department
A center providing vascular care, including diagnosis and treatment for conditions such as peripheral artery disease, aneurysms, and blood vessel disorders, with coordinated servi…
department
A program within the Vascular Medicine Center providing vascular and endovascular surgery, including diagnosis and treatment for conditions such as aneurysms, peripheral artery di…