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Research ALIVE Study

About the Study

The Acute Lung Injury Ventilator Evaluation (ALIVE) Trial is a multi-center research study to identify optimal treatment methods for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). These syndromes are associated with 30-40% mortality with our current standard of care and are responsible for approximately 75,000 deaths in the US yearly. Mechanical ventilation techniques remain the only accepted treatment therapy for patients with these injuries, but ventilation is also associated with segmental lung collapse, increased time on a ventilator and increased incidence of pneumonia. The long-term goal is to improve the health outcomes of patients with acute lung injury and acute respiratory distress syndrome and gain a better understanding of its pathogenesis, prevention and treatment.

Subjects from 8 clinical sites will be entered into the study. Approximately 96 subjects will receive 6 hours each of ARDSNet and APRV ventilator modes. Markers inflammation and injury measured during the two time periods will be compared. This study is funded by the National Trauma Institute (http://www.nationaltraumainstitute.org/)

For more information about this study, please contact Lauren Howard via email or call 617.414.8013.

Download Trial Documents

ALIVE Trial SAE Coordinator

If a subject at your site experiences an SAE that must be reported to the SAE Coordinator, please dial 617.638.5795 and enter pager #4788. This pager is covered 24-hours a day, 7 days a week.

Participating Centers with Principal Investigators

Jeremy Cannon, MD, Brooke Army Medical Center
Peter Burke, MD, Boston Medical Center 
David King, MD, Massachusetts General Hospital 
Timothy Emhoff, MD, University of Massachusetts Memorial Medical Center 
Matthew Lissauer, MD, University of Maryland Medical Center 
Daniel Holena, MD, Hospital of the University of Pennsylvania 
Stephen Cohn, MD, University of Texas Health Center 
Joseph Cuschieri, MD, Harborview Medical Center at the University of Washington

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Call: 617.414.4861
Fax: 617.414.3617

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