Stroke & Cerebrovascular Center
Boston Medical Center
Neurologist-in-Chief, Boston Medical Center
Born in Buenos Aires, Argentina, Dr. Carlos Kase earned his MD degree in Santiago, Chile, from the Catholic University of Chile in May 1967. He pursued further training in Neurology and Vascular Neurology at Massachusetts General Hospital in Boston from 1972-1973, and 1977-1978. Dr. Kase is board-certified by the American Board of Psychiatry and Neurology in Neurology (1980) and also board-certified in the subspecialty of Vascular Neurology (2005).
Dr. Kase joined the Department of Neurology at Boston University School of Medicine in 1984, where he is currently Professor of Neurology and Neurologist-in-Chief, Boston Medical Center. Prior to this, he joined Dr. J.P. Mohr in forming the Neurology Department at the University of South Alabama in Mobile, Alabama in 1978.
Dr. Kase's professional and research interests are in cerebrovascular diseases, with a special interest in intracerebral hemorrhage, carotid artery disease and lacunar infarctions. He has been actively involved in performing clinical studies and clinico-pathologic correlations in intracerebral hemorrhage and cerebral infarction. His research activities have included participation in multicenter NIH-sponsored studies such as the Stroke Data Bank (NINCDS), the Warfarin Aspirin Recurrent Stroke Study (WARSS), the Warfarin vs. Aspirin for Symptomatic Intracranial Disease (WASID) Study, the Secondary Prevention of Small Subcortical Strokes (SPS3) study, and the Insulin Resistance Intervention after Stroke (IRIS) trial, as well as in a number of therapeutic clinical trials. In addition, Dr. Kase has participated in the Framingham Study since 1984, where he has led a number of important epidemiological studies on risk factors in stroke.
Dr. Kase has received numerous distinguished honors for his work in cerebrovascular disease, including Honorary Membership to the Spanish Society of Neurology and the Mexican Association of Cerebrovascular Disease. In 2001, he received the C. Miller Fisher Award for Excellence in Stroke, awarded by the American Stroke Association, Massachusetts Affiliate. In 2002 he was awarded the title of Doctor Honoris Causa from the Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
Lau H, Coffey C, Kase CS, Babikian VL, Pikula A, Romero JR, Nguyen T, Benavente OR, on behalf of the SPS3 investigators. Clinical Trial Participation and Health Behavior Modification: Secondary Prevention of Small Subcortical Strokes (SPS3). J Neurological Disorders and Stroke. February 6, 2015.
Shoamanesh A, Preis SR, Beiser AS, Vasan RS, Benjamin EJ, Kase CS, Wolf PA, DeCarli C, Romero JR, Seshadri S.
Pikula A, Beiser AS, Wang J, Himali JJ, Kelly-Hayes M, Kase CS, Yang Q, Seshadri S, Wolf PA. Lipid and lipoprotein measurements and the risk of ischemic vascular events: Framingham Study. Neurology. 2015 Feb 3;84(5):472-9.
Weinstein G, Preis SR, Beiser AS, Au R, Kelly-Hayes M, Kase CS, Wolf PA, Seshadri S. Cognitive performance after stroke--the Framingham Heart Study. Int J Stroke. 2014 Oct;9 Suppl A100:48-54.
Romero JR, Lau H, Winters MR, Pikula A, Nguyen TN, Kase CS, Babikian VL. Disparities in acute stroke care: role of race and insurance status. Global J of Epid and Public Health (Dec 2014); 1(2): 35-41.
Busza A, Cervantes-Arslanian AM, Kase CS. Clinical Reasoning: A 32-year-old woman with right-sided numbness and word-finding difficulties. Neurology 2014;83(9):e98-e102.
Shoamanesh A, Masoud H, Furey K, Duerfeldt K, Lau H, Romero JR, Pikula A, Teal P, Nguyen TN, Kase CS, Babikian VL. Larger a1/m1 diameter ratio predicts embolic anterior cerebral artery territorial stroke. Stroke 2014;45(9):2798-800
Shoamanesh A, Romero JR, Kase CS. Spontaneous cervical spinal epidural hematoma mimicking acute stroke. Can J Neurol Sci 2014;41(4):533-4.
Romero JR, Preis SR, Beiser A, DeCarli C, Viswanathan A, Martinez-Ramirez S, Kase CS, Wolf PA, Seshadri S. Risk factors, stroke prevention treatments, and prevalence of cerebral microbleeds in the Framingham Heart Study. Stroke 2014;45(5):1492-4.
Culebras A, Messé SR, Chaturvedi S, Kase CS, Gronseth G.Summary of evidence-based guideline update: Prevention of stroke in nonvalvular atrial fibrillation: Report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology 2014 Feb 25;82(8):716-24
Rist PM, Glymour MM, Orav EJ, Kim E, Kase CS, Buring JE, Kurth T. Non-steroidal anti-inflammatory drug use and functional outcome from ischemic cerebral events among women. Eur J Intern Med. 2014 Mar;25(3):255-8.
Rodriguez-Luna D, Dowlatshahi D, Aviv RI, Molina CA, Silva Y, Dzialowski I, Lum C, Czlonkowska A, Boulanger JM, Kase CS, Gubitz G, Bhatia R, Padma V, Roy J, Stewart T, Huynh TJ, Hill MD, Demchuk AM; PREDICT/Sunnybrook ICH CTA Study Group. Venous phase of computed tomography angiography increases spot sign detection, but intracerebral hemorrhage expansion is greater in spot signs detected in arterial phase. Stroke 2014;45(3):734-9.
Voetsch B, Kase C. Management of spontaneous intracerebral hemorrhage. In: Biiler J, Ferro JM, editors. Evidence-based management of stroke. Harley, UK: TFM Publishing Ltd., 2011:175-204.
Pikula A, Beiser AS, Chen TC, Preis SR, Vorgias D, Decarli C, Au R, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S. Serum Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Levels Are Associated With Risk of Stroke and Vascular Brain Injury: Framingham Study.
Alvarez-Sabín J, Maisterra O, Santamarina E, Kase CS. Factors influencing haemorrhagic transformation in ischaemic stroke. Lancet Neurol. 2013 May 30.
Romero JR, Mercado M, Beiser AS, Pikula A, Seshadri S, Kelly-Hayes M, Wolf PA, Kase CS. Transient global amnesia and neurological events: the framingham heart study. Front Neurol 2013;4:47.
Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, Elkind MS, George MG, Hamdan AD, Higashida RT, Hoh BL, Janis LS, Kase CS, Kleindorfer DO, Lee JM, Moseley ME, Peterson ED, Turan TN, Valderrama AL, Vinters HV; on behalf of the American Heart Association Stroke Council. An Updated Definition of Stroke for the 21st Century: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 2013 May 7.
Shoamanesh A, Catanese L, Sakai O, Pikula A, Kase CS. Diffusion-Weighted imaging hyperintensities in intracerebral hemorrhage: Microinfarcts or microbleeds? Ann Neurol. 2013 Jan 29.
Burns JD, Green DM, Lau H, Winter M, Koyfman F, Defusco CM, Holsapple JW, Kase CS. The Effect of a Neurocritical Care Service without a Dedicated Neuro-ICU on Quality of Care in Intracerebral Hemorrhage. Neurocrit Care 2013;18(3):305-12.
Romero JR, Preis SR, Beiser AS, DeCarli C, Lee DY, Viswanathan A, Benjamin EJ, Fontes J, Au R, Pikula A, Wang J, Kase CS, Wolf PA, Irrizary MC, Seshadri S.
White CL, Szychowski JM, Roldan A, Benavente MF, Pretell EJ, Del Brutto OH, Kase CS, Arauz A, Meyer BC, Meissner I, Demaerschalk BM, McClure LA, Coffey CS, Pearce LA, Conwit R, Irby LH, Peri K, Pergola PE, Hart RG, Benavente OR; SPS3 Investigators. Clinical Features and Racial/Ethnic Differences among the 3020 Participants in the Secondary Prevention of Small Subcortical Strokes (SPS3) Trial.
Pikula A, Beiser AS, DeCarli C, Himali JJ, Debette S, Au R, Selhub J, Toffler GH, Wang TJ, Meigs JB, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S.
Demchuk AM, Dowlatshahi D, Rodriguez-Luna D, Molina CA, Blas YS, Dzialowski I, Kobayashi A, Boulanger JM, Lum C, Gubitz G, Padma V, Roy J, Kase CS, Kosior J, Bhatia R, Tymchuk S, Subramaniam S, Gladstone DJ, Hill MD, Aviv RI; PREDICT/Sunnybrook ICH CTA study group. Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign (PREDICT): a prospective observational study. Lancet Neurol 2012;11:307-14.
Westwood AJ, Burns JD, Kase CS. Teaching NeuroImages: Isolated pineal hemorrhage. Neurology. 2011 Oct 18;77(16):e95
Rist PM, Lee IM, Kase CS, Gaziano JM, Kurth T. Physical activity and functional outcomes from cerebral vascular events in men. Stroke 2011;42(12):3352-6.
Nguyen TN, Babikian VL, Romero JR, Pikula A, Kase CS, Jovin TG, Norbash AM. Intra-arterial treatment methods in acute stroke therapy. Frontiers in Endovascular and Interventional Neurology 2011;2:1-10.
Petrea RE, Koyfman F, Pikula A, Romero JR, Viereck J, Babikian VL, Kase CS, Nguyen TN. Acute Stroke, Catheter Related Venous Thrombosis, and Paradoxical Cerebral Embolism: Report of Two Cases. J Neuroimaging 2011;31.
Kurth T, Kase CS, Schürks M, Tzourio C, Buring JE. Migraine and risk of haemorrhagic stroke in women: prospective cohort study. BMJ 2010;341:c3659.
Djoussé L, Gaziano JM, Kase CS, Kurth T. Nut consumption and risk of stroke in US male physicians. Clin Nutr 2010;29(5):605-9.
Kase CS, Nguyen TN. The clinical conundrum of convexal subarachnoid hemorrhage. Neurology 2010;74:874-875.
Rist PM, Berger K, Buring JE, Kase CS, Gaziano JM, Kurth T. Alcohol consumption and functional outcome after stroke in men. Stroke 2010;41(1):141-6.
Kase CS, Albers GW, Bladin C, Fieschi C, Gabbai AA, O'Riordan W, Pineo GF; PREVAIL Investigators. Neurological outcomes in patients with ischemic stroke receiving enoxaparin or heparin for venous thromboembolism prophylaxis: subanalysis of the Prevention of VTE after Acute Ischemic Stroke with LMWH (PREVAIL) study. Stroke 2009;40(11):3532-40.
Debette S, Beiser A, DeCarli C, Au R, Himali JJ, Kelly-Hayes M, Romero JR, Kase CS, Wolf PA, Seshadri S. Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study. Stroke 2010;41(4):600-6.
Pikula A, Böger RH, Beiser AS, Maas R, DeCarli C, Schwedhelm E, Himali JJ, Schulze F, Au R, Kelly-Hayes M, Kase CS, Vasan RS, Wolf PA, Seshadri S. Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study. Stroke 2009;40(9):2959-64.
Ikram MA, Seshadri S, Bis JC, Fornage M, DeStefano AL, Aulchenko YS, Debette S, Lumley T, Folsom AR, van den Herik EG, Bos MJ, Beiser A, Cushman M, Launer LJ, Shahar E, Struchalin M, Du Y, Glazer NL, Rosamond WD, Rivadeneira F, Kelly-Hayes M, Lopez OL, Coresh J, Hofman A, DeCarli C, Heckbert SR, Koudstaal PJ, Yang Q, Smith NL, Kase CS, Rice K, Haritunians T, Roks G, de Kort PL, Taylor KD, de Lau LM, Oostra BA, Uitterlinden AG, Rotter JI, Boerwinkle E, Psaty BM, Mosley TH, van Duijn CM, Breteler MM, Longstreth WT Jr, Wolf PA. Genomewide association studies of stroke. N Engl J Med 2009;360(17):1718-28.
Petrea RE, Beiser AS, Seshadri S, Kelly-Hayes M, Kase CS, Wolf PA. Gender differences in stroke incidence and poststroke disability in the Framingham heart study. Stroke 2009;40:1032-7.
Kase CS, Pineo GF. Prevention of venous thromboembolism after ischemic stroke. Curr Opin Pulm Med. 2008;14(5):389-96.
Broderick J, Connolly S, Feldmann E, Hanley D, Kase C, Krieger D, Mayberg M, Morgenstern L, Ogilvy CS, Vespa P, Zuccarello M. Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007. Stroke 2007;38:2001-2023.
Sherman DG, Albers GW, Bladin C, Fieschi C, Gabbai AA, Kase CS, O'Riordan W, Pineo GF, for the PREVAIL Investigators. The efficacy and safety of enoxaparin versus unfractionated heparin for the prevention of venous thromboembolism after acute ischaemic stroke (PREVAIL study): An open-label randomized comparison. Lancet 2007;369:1347-1355.
Kurth T, Everett BM, Buring JE, Kase CS, Ridker PM, Gaziano JM. Lipid levels and the risk of ischemic stroke in women. Neurology 2007;68(8):556-62.
Salaycik KJ, Kelly-Hayes M, Beiser A, Nguyen AH, Brady SM, Kase CS, Wolf PA. Depressive symptoms and risk of stroke: the Framingham Study. Stroke 2006; 38:16-21.
Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Au R, Kannel WB, Wolf PA. The lifetime risk of stroke: estimates from the Framingham Study. Stroke 2006;37(2):345-50.
Carandang R, Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Kannel WB, Wolf PA. Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years. JAMA 2006;296:2939-2946.
Ivan CS, Seshadri S, Beiser A, Au R, Kase CS, Kelly-Hayes M, Wolf PA: Dementia after stroke: the Framingham Study. Stroke 2004; 35:1264-1268.
Kurth T, Kase CS, Berger K, Schaeffner ES, Buring JE, Gaziano JM. Smoking and the risk of hemorrhagic stroke in men. Stroke 2003;34:1151-1155.
Castillo J, Dávalos A, Álvarez-Sabín J, Pumar JM, Leira R, Silva Y, Montaner J, Kase CS. Molecular signatures of tissue necrosis after intracerebral hemorrhage. Neurology 2002;58:624-629.
Rost NS, Wolf PA, Kase CS, Kelly-Hayes M, Silbershatz H, Massaro JM, D'Agostino RB, Franzblau C, Wilson PW. Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study. Stroke 2001;32(11):2575-9.
Kase CS, Furlan AJ, Wechsler LR, Higashida RT, Rowley HA, Hart RG, Molinari GF, Frederick LS, Roberts HC, Gebel JM, Sila CA, Schulz GA, Roberts RS, Gent M, & the PROACT II Investigators. Symptomatic intracerebral hemorrhage after intra-arterial thrombolysis with prourokinase in acute ischemic stroke: The PROACT II trial. Neurology 2001;57:1603-1610.
Berger K, Ajani UA, Kase CS, Gaziano JM, Buring JE, Glynn RJ, Hennekens CH. Light to moderate alcohol consumption and the risk of stroke among US male physicians. NEJM 1999;341:1557-1564.
Kase CS, Wolf PA, Kelly-Hayes M, Kannel WB, Beiser A, D'Agostino RB. Intellectual decline after stroke: The Framingham Study. Stroke 1998;29:805-812.
Kase CS & Caplan LR: INTRACEREBRAL HEMORRHAGE, Butterworth-Heinemann, Stoneham, MA 1994.
Samuels MA, Feske SK, Daffner KR, Kase CS, Preston DC, Rolak LA, Spierings ELH, Sudarsky LR & Wen PY: OFFICE PRACTICE OF NEUROLOGY, 2nd Edition, Churchill-Livingstone, Philadelphia, PA 2003.