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Participate in Research or Clinical Trials

For general information about participating in research, see http://www.bumc.bu.edu/ohra/ and https://www.bmc.org/research-operations/participate-research.

If you have any questions or do not see the study you are interested in, please contact the Clinical Trial Office at [email protected]

Project Title Link Principal Investigator Department Section Study Team Contact E-mail Study Team Contact Phone
PREcision Event Monitoring for PatienTs with Heart Failure using HeartLogic (PREEMPT-HF) Kevin Monahan Medicine Cardiology 617-638-8718
SELECT - Semaglutide effects on cardiovascular outcomes in people with overweight or obesity Caroline Apovian Medicine Endocrinology, Diabetes and Nutrition 617-414-2935
Mylan GAZELLE Trial: MYL-1601D-3001 - A Randomized, Multicenter, Open-Label, Parallel-Group Clinical Study Comparing the Safety and Efficacy of MYL-1601D with NovoLog in Type 1 Diabetes Mellitus Patients Devin Steenkamp Medicine Endocrinology, Diabetes and Nutrition 617-414-2935
SWITCH Pro: A randomised, cross-over, open-label, multi-centre trial comparing the effect of insulin degludec and insulin glargine 100U/mL, with or without OADs in subjects with type 2 diabetes using flash glucose monitoring Devin Steenkamp Medicine Endocrinology, Diabetes and Nutrition 617-414-2935
Mona Lisa Katharine White Obstetrics / Gynecology General Gynecology 617-414-5176
ANCHOR Elizabeth Stier Obstetrics / Gynecology General Gynecology 214-412-9801
NAVIGATE-ESUS Viken Babikian Neurology Stroke 617-353-2087
Vedolizumab IV Crohn's Francis Farraye Medicine Gastroenterology 617-353-2087
HT-3951-201/PXL222158 Courtney Takahashi Neurology Stroke 617-353-2087
Macitentan Elizabeth Klings Medicine Pulmonary, Allergy and Critical Care 617-353-2087
BMS-986141 Rafael Jose Romero Neurology Stroke 617-353-2087
REPLACE Elizabeth Klings Arthritis Center N/A 617-353-2087
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 3 STUDY TO EVALUATE THE SAFETY AND EFFICACY OF CCX168 (ACACOPAN) IN PATIENTS WITH ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA)-ASSOCIATED VASCULITIS TREATED CONCOMITANTLY WITH RITUXIMAB OR CYCLOPHOSPHAMIDE/AZATHIOPRINE Paul Monach Medicine Rheumatology 617-353-2087
INTREPID Anna Cervantes-Arslanian Neurology Stroke 617-353-2087
REACT: pRevention and trEatment of vAsospasm with ClazosenTan Thanh Nguyen Neurology Stroke 617-353-2087
AdreView™ Myocardial Imaging for Risk Evaluation – A multicentre trial to guide ICD implantation in NYHA class II & III heart failure patients with 30%≤LVEF≤35%. ADMIRE-ICD Robert Helm Medicine Cardiology 617-353-2087
IWALQQ-OA Deepak Kumar Radiology N/A 617-358-3125
DIAGNOSE CTE Robert Stern Neurology N/A 617-358-5443
Protocol H8A-MC-LZAZ Robert Stern Alzheimers Disease Center N/A 617-414-1196
Registry of Amyloid Positive Patients for Alzheimer’s Disease Drug Research Trials (RAmP) Robert Stern Neurology N/A 617-414-1196
Alcohol Disorder hosPital Treatment (ADOPT) Study Richard Saitz Medicine General Internal Medicine 617-414-1374
CTN-0049 Outcomes, HCV Margaret Sullivan Medicine Infectious Diseases 617-414-1395
OTO-104 Kenneth Grundfast Otolaryngology - Head and Neck Surgery N/A 617-414-1756
BP39207 BASMISANIL David Henderson Psychiatry N/A 617-414-1911
Anifrolumab Ramon Bonegio Medicine Nephrology 617-414-1968
Genentech GA30044 Ramon Bonegio Medicine Nephrology 617-414-1968
Btk inhibitor LTE Ramon Bonegio Medicine Nephrology 617-414-1968
ALXN1210 Jean Francis Medicine Nephrology 617-414-1968
AURORA Ramon Bonegio Medicine Nephrology 617-414-1968
APS Prevention David Henderson Psychiatry N/A 617-414-1987
Efficacy and safety of SAR156597 in the treatment of diffuse cutaneous Systemic Sclerosis (dcSSc): A randomized, double-blind, placebo-controlled, 24-week, proof of concept study Robert Simms Arthritis Center N/A 617-414-2507
DMF-PRO16070614 Robert Simms Medicine Rheumatology 617-414-2507
GSK, 201247 Robert Simms Medicine Rheumatology 617-414-2507
SCLERODERMA LUNG STUDY III SLS3 Robert Simms Medicine Rheumatology 617-414-2507
Rituximab Robert Simms Medicine Pulmonary, Allergy and Critical Care 617-414-2507
Abatacept (CTLA4-Ig) for the Treatment of Relapsing, Non-Severe, Granulomatosis with Polyangiitis (Wegener's) (ABROGATE) Paul Monach Medicine Rheumatology 617-414-2512
REPRIEVE Nina Lin Medicine Infectious Diseases 617-414-2842
Smoking Cessation Nina Lin Medicine Infectious Diseases 617-414-2842
Gilead GS-US-380-4580 Ioana Bica Medicine Infectious Diseases 617-414-2842
Improving Outcomes in Neonatal Abstinence Syndrome (NAS) Michael Silverstein Pediatrics Pediatric General 617-414-3827
TREETOP Glenn Markenson Obstetrics / Gynecology Maternal-Fetal Medicine 617-414-5176
Double-Blind Placebo Controlled Trial of the Treatment of Chronic Laryngitis with Amitriptyline Pieter Noordzij Otolaryngology - Head and Neck Surgery N/A 617-414-5449
Pfizer Rivipansel Hedy Smith Medicine Hematology and Medical Oncology 617-414-5729
A Study to Compare Bone Marrow Transplantation to Standard Care in Adolescents and Young Adults with Severe Sickle Cell Disease Lillian McMahon Medicine General Internal Medicine 617-414-5729
GBT440 Lillian McMahon Medicine General Internal Medicine 617-414-5729
An Open Label Extension Study of GBT440 Administered Orally to Patients with Sickle Cell Disease Who Have Participated in GBT440 Clinical Trials Lillian McMahon Medicine Hematology and Medical Oncology 617-414-5729
A Phase IIb Randomized, Double-Blind, Placebo-Controlled Multi-Center Study to Assess the Safety, Tolerability, and Efficacy of Riociguat in Patients with Sickle Cell Diseases (STERIO-SCD) Elizabeth Klings Medicine Hematology and Medical Oncology 617-414-5729
PHARMACOKINETIC PROPERTIES OF ANTIRETROVIRAL AND RELATED DRUGS DURING PREGNANCY AND POSTPARTUM (IMPAACT P1026S) Mark Mirochnick Pediatrics Pediatric Infectious Diseases 617-414-5813
AbbVie Study - M16-123 Vishaka Sabharwal Pediatrics Pediatric Infectious Diseases 617-414-5813
PHASE I/II, MULTI-CENTER, OPEN-LABEL PHARMACOKINETIC, SAFETY, TOLERABILITY AND ANTIVIRAL ACTIVITY OF GSK1349572, A NOVEL INTEGRASE INHIBITOR, IN COMBINATION REGIMENS IN HIV-1 INFECTED INFANTS, CHILDREN AND ADOLESCENTS (IMPAACT P1093) Stephen Pelton Pediatrics Pediatric Infectious Diseases 617-414-5813
WIC2 Suzanne Mitchell Family Medicine N/A 617-414-6207
A Prospective Randomized Trial to Assess PO versus IV Antibiotics for the Treatment of Early Post-op Wound Infection after Extremity Fractures Paul Tornetta Orthopaedic Surgery Orthopaedic Surgery 617-414-6295
Pain - Orthopedic Trauma Paul Tornetta Orthopaedic Surgery Orthopaedic Surgery 617-414-6295
OXYGEN Paul Tornetta Orthopaedic Surgery Orthopaedic Surgery 617-414-6295
I.M.P.R.E.S.S Paul Tornetta Orthopaedic Surgery Orthopaedic Surgery 617-414-6295
Best Endovasc vs Best Surg Thera Jeffrey Kalish Surgery Vascular and Endovascular Surgery 617-414-6832
The Impact of Diabetes on REvascularization in BEST-CLI (TIDE) Jeffrey Kalish Surgery Vascular and Endovascular Surgery 617-414-6832
PRESERVE Jeffrey Kalish Surgery Vascular and Endovascular Surgery 617-414-6832
Study of SR vs SAbR in NSCLC Kei Suzuki Surgery Thoracic Surgery 617-414-6832
Ranger Alik Farber Surgery Vascular and Endovascular Surgery 617-414-6832
Iodixanol Jeffrey Siracuse Surgery Vascular and Endovascular Surgery 617-414-6832
VasQ arteriovenous fistula Alik Farber Surgery Vascular and Endovascular Surgery 617-414-6832
PICO- Lower Extremity Bypass Jeffrey Siracuse Surgery Vascular and Endovascular Surgery 617-414-6832
Dose-response Relationship Study of S42909 on Leg Ulcer Healing Alik Farber Surgery Vascular and Endovascular Surgery 617-414-6832
NAION Crandall Peeler Ophthalmology N/A 617-414-8804
Zoster Eye Disease Study: A multi-center, randomized, double-masked, placebo-controlled clinical trial of suppressive valacyclovir for one year in immunocompetent study participants with an episode of dendriform epithelial keratitis, stromal keratitis, endothelial keratitis, and/or iritis due to Herpes Zoster Ophthalmicus (HZO) in the year prior to enrollment. (ZEDS) Hyunjoo Lee Ophthalmology N/A 617-414-8804
IXT5 Stephen Christiansen Ophthalmology N/A 617-414-8805
AMC 092: A multicenter observational and feasibility study of excision of superficially invasive squamous cell carcinoma (SISCCA) of the anal canal and perianus in HIV-infected persons Elizabeth Stier Obstetrics / Gynecology General Gynecology 617-608-7020
Janssen: Efficacy and Safety of Rivaroxaban Prophylaxis Compared with Placebo in AmbulatoryCancer Patients Initiating Systemic Cancer Therapy and at High Risk for Venous Thromboembolism (RIVA) John Sloan Medicine Hematology and Medical Oncology 617-638-4178
Riociguat in HIV patients Elizabeth Klings Pulmonary Center N/A 617-638-4344
A Phase II Multi-Center Study of High-Dose Cyclophosphamide and Antithymocyte Globulin Followed by Autologous Hematopoietic Cell Transplantation with Post Transplant Maintenance for the Treatment of Systemic Sclerosis Robert Simms Medicine Rheumatology 617-638-4475
Triton Study Elizabeth Klings Medicine Rheumatology 617-638-4475
RANGER STudy Elizabeth Klings Medicine Rheumatology 617-638-4475
Tafamidis Meglumine John Berk Medicine Amyloid Research and Training Program 617-638-4591
TOL-001 John Berk Amyloidosis Center N/A 617-638-4591
An open label, multicenter study evaluating the Safety and Imaging Characteristics of a new PET Scan Test in Healthly Volunteers, Subjects with Mild Cognitive Impairment and Subjects with Alzheimer's Disease Dementia Robert Stern Alzheimers Disease Center N/A 617-638-5368
Follow-up Avid PET Scan Study Robert Stern Neurology N/A 617-638-5368
ARAMIS-A randomized multicenter study for isolated skin vasculitis Paul Monach Medicine Rheumatology 617-638-5383
CUTIS-Clinical transcriptomics in systemic vasculitis Christina Lam Medicine Rheumatology 617-638-5383
BRAVOS Robert Simms Medicine Rheumatology 617-638-5383
Lenabasum Robert Simms Medicine Rheumatology 617-638-5383
The LEARN Study Robert Stern Neurology N/A 617-638-5670
Daybreak Robert Stern Neurology N/A 617-638-5670
ADNI-3 Ronald Killiany Neurology N/A 617-638-5670
Early Study Robert Stern Neurology N/A 617-638-5670
Dexamethasone Plus MLN9708 Vaishali Sanchorawala Medicine Hematology and Medical Oncology 617-638-6521
SWOG #S1207: Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk, Hormone Receptor-Positive and HER2/neu Negative Breast Cancer Lauren Oshry Cancer Care Center N/A 617-638-6521
NRG #HN001 Minh-Tam Truong Medicine Hematology and Medical Oncology 617-638-6521
Pembrolizumab (MK-3475) Kevan Hartshorn Cancer Care Center N/A 617-638-6521
LCCC 1637: Brentuximab Vedotin with Cyclophosphamide, Doxorubicin, Etoposide, and Prednisone (BV-CHEP) for the treatment of Adult T-Cell Leukemia/Lymphoma: A Phase II Trial of the Rare Lymphoma Working Group Mark Sloan Medicine Hematology and Medical Oncology 617-638-6521
DALF 1016: A Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Two Dose Strengths of Dalfampridine Extended Release Tablets for Treatment of Stable Walking Deficits in Post-Ischemic Stroke Brigid Dwyer Neurology Stroke 617-638-6527
W1239335 Sharmeel Wasan Medicine Gastroenterology 617-638-6527
Fecal Microbiota Therapy (FMT) Francis Farraye Medicine Gastroenterology 617-638-6527
Oral RPC1063, Phase 3, Multi, Rando, Double Blind, of Oral RPC1063 Francis Farraye Medicine Gastroenterology 617-638-6527
The Regenerate Study 747-303 Michelle Long Medicine Gastroenterology 617-638-6527
A Phase 3, Multi, OLE trial of Oral RPC0163 Francis Farraye Medicine Gastroenterology 617-638-6527
GED-0301 Francis Farraye Medicine Medicine 617-638-6527
Vedolizumab Sharmeel Wasan Medicine Gastroenterology 617-638-6527
Dose Finding Study in Central Nervous System (CNS) Magnetic Resonance Imaging (MRI) Osamu Sakai Radiology N/A 617-638-6591
IDEAS Study   Medicine Amyloid Research and Training Program 617-638-6591
CVT009 Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
Parkinson's Progression Markers Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
CVT-301 Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
Intec DD Study Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
Intec OLE Study Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
SURE-PD3 Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
228PD201 Marie-Helene Saint-Hilaire Neurology N/A 617-638-7745
XC-8998 for Essential Tremor Okeanis Vaou Neurology N/A 617-638-7747
P2B Marie-Helene Saint-Hilaire Neurology N/A 617-638-7747
AMC #085: A Pilot Trial of AVD and Brentuximab Vedotin (SGN-35) in the treatment of stage II-IV HIV-associated Hodgkin Lymphoma Mark Sloan Medicine Hematology and Medical Oncology 617-638-8213
SWOG #S1320 Adam Lerner Medicine Hematology and Medical Oncology 617-638-8213
NRG #GI001: Randomized Phase III Study of Focal Radiation Therapy for Unresectable, Localized Intrahepatic Cholangiocarcinoma   Cancer Care Center N/A 617-638-8213
EA5142: Adjuvant Nivolumab in Resected Lung Cancers (ANVIL) - A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers. Peter Everett Medicine Hematology and Medical Oncology 617-638-8213
A021501 - Preoperative Extended Chemotherapy Vs. Chemotherapy Plus Hypofractioned Radiation Therapy for Borderline Resectable Adenocarcinoma of the Head of the Pancreas Kevan Hartshorn Medicine Hematology and Medical Oncology 617-638-8213
S1605 - Atezolizumab in Treating Patients With Recurrent BCG-Unresponsive Non-muscle Invasive Bladder Cancer Gretchen Gignac Medicine Hematology and Medical Oncology 617-638-8213
S1418 - A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer with >/= 1 CM Residual Invasive Cancer or Positive Lymph Nodes (ypN+) after Neoadjuvant Chemotherapy Lauren Oshry Medicine Hematology and Medical Oncology 617-638-8213
EA8143: A Phase 3 Randomized Study Comparing Perioperative Nivolumab vs. Observation in Patients with Localized Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC) Gretchen Gignac Medicine Hematology and Medical Oncology 617-638-8213
GU002 - PHASE II-III TRIAL OF ADJUVANT RADIOTHERAPY AND ANDROGEN DEPRIVATION FOLLOWING RADICAL PROSTATECTOMY WITH OR WITHOUT ADJUVANT DOCETAXEL Gretchen Gignac Medicine Hematology and Medical Oncology 617-638-8213
NRG-LU002 - Maintenance Systemic Therapy Versus Consolidative Stereotactic Body Radiation Therapy (SBRT) Plus Maintenance Systemic Therapy For Limited Metastatic Non-Small Cell Lung Cancer (NSCLC): A Randomized Phase II/III Trial Marjory Charlot Medicine Hematology and Medical Oncology 617-638-8213
A031501 - PHASE III RANDOMIZED ADJUVANT STUDY OF MK-3475 (PEMBROLIZUMAB) IN MUSCLE INVASIVE AND LOCALLY ADVANCED UROTHELIAL CARCINOMA (AMBASSADOR) VERSUS OBSERVATION Gretchen Gignac Medicine Hematology and Medical Oncology 617-638-8213
NRG-HN004: Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Stage III-IVB Head and Neck Cancer with a Contraindication to Cisplatin: Safety Lead-In Portion Minh-Tam Truong Medicine Hematology and Medical Oncology 617-638-8213
BMS- CA2099KD Gretchen Gignac Cancer Care Center N/A 617-638-8213
A021602 - Cabozantinib vs Placebo for NETs Matthew H Kulke Cancer Care Center N/A 617-638-8213
Merck 671: A Phase III, Randomized, Double-blind Trial of Platinum Doublet Chemotherapy +/-Pembrolizumab (MK-3475) as Neoadjuvant/Adjuvant Therapy for Participants with Resectable Stage IIB or IIIA Non-small Cell Lung Cancer (NSCLC) (KEYNOTE-671) Peter Everett Cancer Care Center N/A 617-638-8213
RTOG-3507: A randomized phase II study of Pembrolizumab(Keytruda®) plus Stereotactic Re-irradiation versus SBRT alone for Locoregionally recurrent or second primary head and neck carcinoma. Michael Dyer Cancer Care Center N/A 617-638-8213
DARA-MMY3019: A Phase 3 Study Comparing Daratumumab, VELCADE (bortezomib), Lenalidomide, and Dexamethasone (D-VRd) with VELCADE, Lenalidomide, and Dexamethasone (VRd) in Subjects with Untreated Multiple Myeloma and for Whom Hematopoietic Stem Cell Transplant is Not Planned as Initial Therapy. Vaishali Sanchorawala Cancer Care Center N/A 617-638-8213
Naloxone Hydrochloride for pruritus Adam Lerner Cancer Care Center N/A 617-638-8213
NRG-GU003 Ariel Hirsch Radiation Oncology N/A 617-638-8213
Merck 598 Peter Everett Cancer Care Center N/A 617-638-8213
S1702 Vaishali Sanchorawala Medicine Hematology and Medical Oncology 617-638-8213
RTOG #R0534: A Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPPORT) in Prostate Cancer Patients with a Rising PSA After Radical Prostatectomy Ariel Hirsch Radiation Oncology N/A 617-638-8260
RTOG #R0920: A PHASE III STUDY OF POSTOPERATIVE RADIATION THERAPY (IMRT) +/- CETUXIMAB FOR LOCALLY-ADVANCED RESECTED HEAD AND NECK CANCER Minh-Tam Truong Radiation Oncology N/A 617-638-8260
FEASIBILITY/OUTCOMES STUDY OF HYPOFRACTIONATED STEREOTACTIC BODY RADIATION THERAPY AS A BOOST TO THE PROSTATE FOR TREATMENT OF LOCALIZED, NON-METASTATIC, HIGH RISK PROSTATE CANCER Ariel Hirsch Radiation Oncology N/A 617-638-8260
CTSU #E1412: Randomized Phase II Open Label Study of Lenalidomide R-CHOP (R2CHOP) vs RCHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone) in Patients with Newly Diagnosed Diffuse Large B Cell Lymphoma John Sloan Medicine Hematology and Medical Oncology 617-638-8260
A011401 - RANDOMIZED PHASE III TRIAL EVALUATING THE ROLE OF WEIGHT LOSS IN ADJUVANT TREATMENT OF OVERWEIGHT AND OBESE WOMEN WITH EARLY BREAST CANCER Lauren Oshry Medicine Hematology and Medical Oncology 617-638-8260
A011202 Michael Cassidy Cancer Care Center N/A 617-638-8260
NRG #BN001: Randomized Phase II Trial of Hypofractionated Dose-Escalated Photon IMRT or Proton Beam Therapy versus Conventional Photon Irradiation with Concomitant and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma Minh-Tam Truong Cancer Care Center N/A 617-638-8261
Study Title: SWOG #S1500: A Randomized, Phase II Efficacy Assessment of Multiple MET Kinase Inhibitors (Cabozantinib [NSC #761968], Crizotinib [NSC #749005], Savolitinib [NSC #785348], and Sunitinib [NSC #736511]) in Metastatic Papillary Renal Carcinoma (PAPMET) Gretchen Gignac Cancer Care Center N/A 617-638-8261
CTSU #A081105: Randomized Double Blind Placebo Controlled Study of Erlotinib or Placebo in Patients with Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-Small Cell Lung Cancer (NSCLC) Peter Everett Cancer Care Center N/A 617-638-8261
DFCI- Adjuvant nivolumab and lirilumab in patients with relapsed, resectable squamous cell carcinoma of the head and neck Peter Everett Cancer Care Center N/A 617-638-8261
SWOG #S1400 Peter Everett Cancer Care Center N/A 617-638-8261
Evomela Shayna Sarosiek Cancer Care Center N/A 617-638-8274
Proteon Jeffrey Siracuse Surgery Vascular and Endovascular Surgery 617-638-8622
Primatrix Hau Pham Surgery Podiatry 617-638-8622
ORI-16-003 Hau Pham Surgery Podiatry 617-638-8622
Topstone Hau Pham Surgery Podiatry 617-638-8622
Cx601 Investigator’s Brochure. Therapy with expanded human allogeneic adult stem cells extracted from adipose tissue. Jason Hall Surgery Colon and Rectal Surgery 617-638-8622
ISCHEMIA Claudia Hochberg Medicine Cardiology 617-638-8716
Absorb™ BVS Alice Jacobs Medicine Cardiology 617-638-8716
Decamp 2 Ehab Billatos Medicine Computational Biomedicine 617-638-8716
Multicenter, randomized, double blind, placebo controlled, phase 2 study evaluating the safety and efficacy of different doses of IW-1973 over 12 weeks in patients with heart failure with preserved ejection fraction Flora Sam Medicine Cardiology 617-638-8716
Effi and Safety of NEOD001 Vaishali Sanchorawala Medicine Hematology and Medical Oncology 781-207-7591
Dara Janssen Vaishali Sanchorawala Cancer Care Center N/A 781-207-7591
MirenaE Katharine White Obstetrics / Gynecology General Gynecology 617-414-7304