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Reproductive Endocrinology
Inferility

A. Evaluation


1. Describe the classification of infertility (ie, primary versus secondary).
2. List the principal causes of primary and secondary infertility.
3. Elicit a pertinent history to determine the most likely cause of infertility.
4. Perform a focused physical examination to determine the most likely cause of infertility.
5. Perform selected diagnostic tests to determine the most likely cause of infertility, such as:

a. Review of basal body temperature chart
b. Endometrial biopsy
c. Hysterosalpingography
d. Laparoscopy
e. Microbiologic cultures of the lower and upper genital tract

6. Interpret the results of other diagnostic tests, such as:

a. Endometrial histology
b. Semen analysis and culture
c. Sperm antibody test
d. Urine ovulation indicator
e. Blood assays

7. Treat infertile patients who have irregular ovulation with nongonadotropin therapy, such as:

a. Clomiphene citrate
b. Prednisone
c. Insulin-sensitivity agents such as metformin

8. Perform selected surgical procedures to correct conditions that cause infertility, such as:

a. Lysis of pelvic adhesions
b. Excision of endometriomas
c. Fulguration of endometriotic implants

9. describe the indications for referral of the patient to a subspecialist for treatment (eg, gonadotropin therapy, assisted reproductive technologies [ART]).
10. Counsel patients about the long-term prognosis for their condition and alternatives to childbearing, such as adoption.

B. Reproductive technologies


1. Describe the indications for ART procedures, such as:

a. In vitro fertilization (IVF)
b. Gamete intrafallopian transfer (GIFT)
c. Zygote intrafallopian transfer (ZIFT)
d. Intracytoplasmic sperm injection (ICSI)
e. Gamete donation
f. Preimplantation genetic diagnosis

2. Describe the prognosis for, and complications of, ART.

C. Developmental anomalies of the urogenital tract


1. Describe the major developmental anomalies and their implications for sexual functioning, menstrual outflow, fertility and reproductive outcome, including:

a. Hymenal abnormalities, such as imperforate hymen
b. Vaginal agenesis
c. Vaginal septum

(1) Obstructive and non obstructive
(2) Longitudinal and transverse

d. Uterine septum
e. Unicornuate or bicornuate uterus
f. Uterine didelphys
g. Uterine horn

2. Describe the features of a patient’s history suggestive of a developmental anomaly of the urogenital tract.
3. Perform a focused physical examination to identify a developmental anomaly of the urogenital tract and associated somatic anomalies.
4. Perform procedures (eg, ultrasound examination, hysterosalpingography, examination under anesthesia, and hysteroscopy and laparoscopy) to confirm the diagnosis of a developmental anomaly of the urogenital tract.
5. Interpret the following tests to help to confirm the diagnosis of a developmental anomaly and determine the etiology and their implications:

a. Ulrasonography
b. Endocrinologic assays
c. Peripheral blood karyotype assessments
d. CT/MRI scan

6. Describe appropriate medical and surgical treatments for patients with developmental anomalies.
7. Counsel affected patients and their parents about the impact of genital tract anomalies on reproduction.
8. Describe the indications for referral to a subspecialist.

D. Recurrent pregnancy loss


1. Describe the most common causes of recurrent first-trimester pregnancy loss.
2. Elicit a pertinent history in a patient with recurrent first-trimester pregnancy losses, such as:

a. Pedigree analysis
b. Detection of underlying medical disorders
c. Exposure to toxins

3. Perform a focused physical examination to identify possible causes of recurrent first-trimester pregnancy loss, such as:

a. Genital tract malformations
b. Galactorrhea
c. Hypothyroidism
d. Autoimmune disease

4. Perform selected diagnostic tests to determine the etiology of recurrent early pregnancy loss, for example:

a. Microbiologic cultures of the genital tract
b. Hysteroscopy
c. Endometrial biopsy

5. Interpret the results of other diagnostic tests, such as:

a. Serum prolactin
b. Thyroid function tests
c. Serum progesterone
d. Serologic tests for connective tissue disease
e. Peripheral blood karyotype
f. Hysterosalpingography

6. Treat medically and surgically patients with a history of recurrent pregnancy loss.
7. Counsel patients about the prognosis for successful treatment and the feasibility of alternative approaches, such as assisted reproductive technology and adoption.

Reproductive health care issues


1. Describe the principal reproductive health care issues of adolescents with developmental delays.
2. Describe the principal reproductive health care issues of physically disabled adolescents.






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