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OB PGY1/PGY2
Basic Science/Mechanisms of Disease

Genetics

1. Describe the organization and replication of DNA.
2. Describe the processes of cell division: mitosis and meiosis.
3. Describe the clinical significance of karyotype abnormalities, such as:

a. Trisomy
b. Monosomy
c. Deletions
d. Inversions

4. Describe the clinical significance of heritable diseases, such as cystic fibrosis, Tay-Sachs disease, and hemophilia

Pharmacology

1. Describe the role for nutritional supplementation in pregnancy (eg, iron, folic acid).
2. Describe the impact of pregnancy on serum and tissue drug concentrations and drug efficacy.
3. Describe the factors that influence transplacental drug transfer, such as:

a. Molecular size
b. Lipid solubility
c. Degree of ionization at physiologic pH
d. Protein binding

4. Describe the possible teratogenic effects of prescription drugs in pregnancy, such as:

a. Tetracycline
b. Angiotensin-converting enzyme inhibitors
c. Quinolone antibiotics
d. Lithium
e. Isotretinoin
f. Seizure medications

5. Describe the possible teratogenic effects of nonprescription drugs, such as:

a. Alcohol
b. Heroin
c. Cocaine
d. Tobacco

Embryology and developmental biology

1. Describe the normal process of gametogenesis.
2. Describe the normal process of fertilization.
3. Describe the normal process of embryologic development of the singleton pregnancy.
4. Describe the embryology of multiple gestations.

Anatomy

1. Describe the muscular and vascular anatomy of the pelvis and vulva.
2. Describe the anatomic changes in the mother caused by normal physiologic adaptation to pregnancy.
3. Describe the anatomic changes that occur during the intrapartum period, such as cervical effacement and dilatation.
4. Describe the anatomic changes that occur during the puerperium, such as alterations in the breast and uterine involution.

Microbiology and immunology

1. Describe the principal features of the host immunologic response:

a. Antigen processing and recognition
b. Hormonal-mediated immunity
c. Cell-mediated immunity
d. Phagocytosis
e. Cytokine activation
f. Complement activation

2. Describe how the maternal immune response is altered by pregnancy.
3. Describe the basic features and timing of development of the fetal immunologic response.
4. Describe the etiology and pathophysiology of the most common genital tract infections.
5. Describe the association between genital tract infection and adverse perinatal outcomes, such as:

a. Preterm labor
b. Preterm premature rupture of membranes
c. Neonatal infection
d. Material infection




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