Center for HIV/AIDS Care & Research

Research

Thomas E. Van Dyke, DDS

Professor of Oral Biology and Periodontology
Director, Clinical Research Center

Boston University Goldman School of Dental Medicine
Boston University Goldman School of Dental Medicine
Department of Periodontology and Oral Biology
100 East Newton Street, G-05
Boston, MA 02118
P: 617.638.4758
tvandyke@bu.edu

Education

MS State University of New York, Buffalo
PhD State University of New York, Buffalo
DDS Case Western University, Cleveland, Ohio

Research

In development

Selected Publications

1.       Gronert K, Kantarci A, Levy B, Odparlik S, Hasturk H, Badwey, JA, Colgan SP, Van Dyke, TE, and Serhan CN. A Molecular Defect in Intercellular Lipid Signaling in Human Neutrophils in Localized Aggressive Periodontal Tissue Damage.  J. Immunol Feb 1;172(3):1856-1861, 2004

2.      Ohira T, Bannenberg G, Arita M, Takahashi M, Ge Q, Van Dyke TE, Stahl G, Serhan CN, and Badwey J.  A Stable Aspirin-Triggered Lipoxin A₄ Analog Blocks Phosphorylation of Leukocyte-Specific Protein 1 in Human Neutrophils.  J Immunol Aug 1:173(3):2091-8, 2004

3.      Serhan CN, Jain A, Marleau S, Clish C, Kantarci A, Behbehani B, Colgan SP, Stahl GL, Merched A, Petasis NA, Chan L, and Van Dyke TE.  Reduced Inflammation and Tissue Damage in Transgenic Rabbits Overexpressing 15-Lipoxygenase and Endogenous Anti-inflammatory Lipid Mediators.  J of Immunol, Dec 15:171(12):6856-6865 2003.

4.      Ariel A, Fredman G, Sun Y, Kantarci A, Van Dyke TE, Luster AD and Serhan CN.  Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression.  Nat Immunol. 2006 Nov;7(11):1209-16. Epub 2006 Oct 1

5.      Gyurko R, Siqueira CC, Caldon N, Gao L, Kantarci A, and Van Dyke TE. Chronic Hyperglycemia Predisposes to Exaggerated Inflammatory Response and Leukocyte Dysfunction in Akita Mice. J Immunol. Nov 15;177(10):7250-6, 2006

6.      Hasturk H, Kantarci A, Ohira T, Arita M, Ebrahimi N, Chiang N, Petasis NA, Levy BD, Serhan CN, and Van Dyke TE. RvE1 Protects from Local Inflammation and Osteoclast- Mediated Bone Destruction in Periodontitis. FASEB Feb;20(2):401-3 Epub 2005 Dec 22, 2006

7.      Hasturk H, Kantarci A, Goguet-Surmenian E, Blackwood A, Andry C, Serhan CN, Van Dyke TE. Resolvin E1 Regulates Inflammation At The Cellular And Tissue Level And Restores Tissue Homeostasis In Vivo. J Immunol Nov 15:179 (10):7021-9 2007

8.       Serhan CN, Chiang N, and Van Dyke TE.  Resolving Inflammation: Dual Anti-Inflammatory and Pro-Resolution Lipid Mediators.  Nature Reviews/Immunology May (8) 1-13, 2008

9.      Ayilavarapu S, Kantarci A, Fredman G, Turkoglu O, Omori K, Liu H, Iwata T, Yagi M, Hasturk H, and Van Dyke TE Diabetes-induced Oxidative Stress is Mediated by iPLA₂ in PMN.  J. Immunol, in press, 2010. 

10.  Ohira, T, Arita, M, Omori, K, Recchiuti, A, Van Dyke, TE, and Serhan, CN.  RvE1 Receptor Activation Signals Phosphorylation and Phagocytosis. J. Biol. Chem., in press, 2010