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Geriatrics

Research

Recent Publications

Our clinician-researchers publish frequently in leading medical journals and use their research to bring innovation in teaching geriatrics and improving the care of vulnerable older adults. Included below (categorized by topic) are articles published from 2011-2016 authored by one or more BMC clinician-researchers in the Section of Geriatrics.   

Alzheimer's Disease
Cancer Care in Older Adults
Caregivers
Chronic Kidney Disease
Exceptional Longevity
Exercise in the Elderly
Frailty
Geriatrics Education
Hospitalizations
Internal Medicine
Mobility
Nursing Homes
Patient Relations

Alzheimer's Disease

Kopits IM, Chen C, Roberts JS, Uhlmann W, Green RC. Willingness to pay for genetic testing for Alzheimer’s Disease: a measure of personal utility. Genet Test Mol Biomarkers. 2011 Dec;15(12):871-5.

Cancer Care in Older Adults

Silliman RA. Commentary: Ascertaining late Effects of Breast Cancer and Its Treatment: Can We Build a Better Mouse Trap? Epidemiology. 2016 Jan;27(1):2-5.

Eng JA, Clough-Gorr K, Cabral HJ, Silliman RA. Predicting 5- and 10-year survival in older women with early-stage breast cancer: self-rated health and walking ability. J Am Geriatr Soc. 2015 Apr;63(4):757-62.

Ording AG, Boffetta P, Garne JP, Nyström PM, Cronin-Fenton D, Frøslev T, Silliman R, Sørensen HT, Lash TL. Relative mortality rates from incident chronic diseases among breast cancer survivors--a 14 year follow-up of five-year survivors diagnosed in Denmark between 1994 and 2007. Eur J Cancer. 2015 Apr;51(6):767-75.

Jordan JH, Thwin SS, Lash TL, Buist DS, Field TS, Haque R, Pawloski PA, Petersen HV, Prout MN, Quinn VP, Yood MU, Silliman RA, Geiger AM. Incident comorbidities and all-cause mortality among 5-year survivors of Stage I and II breast cancer diagnosed at age 65 or older: a prospective-matched cohort study. Breast Cancer Res Treat. 2014 Jul;146(2):401-9.

Haque R, Prout M, Geiger AM, Kamineni A, Thwin SS,  Avila CC, Silliman RA, Quinn V, Yood MU. Comorbidities and Cardiovascular Disease Risk in Older Breast Cancer Survivors. Am J Managed Care 2014;20(1):86-92.

Jordan JH, Thwin SS, Lash TL, Buist DS, Field TS, Haque R, Pawloski PA, Petersen HV, Prout MN, Quinn VP, Yood MU, Silliman RA, Geiger AM. Incident comorbidities and all-cause mortality among 5-year survivors of Stage I and II breast cancer diagnosed at age 65 or older: a prospective-matched cohort study. Breast Cancer Res Treat. 2014 Jul;146(2):401-9.

Lash TL, Thwin SS, Ulcickas Yood M, Geiger AM, Bosco J, Quinn VP, Field TS, Pawloski PA, Silliman RA. Comprehensive evaluation of the incidence of late effects in 5-year survivors of breast cancer. Breast Cancer Res Treat. 2014 Apr;144(3):643-63.

Mandelblatt JS, Stern RA, Luta G, McGuckin ME, Clapp JD, Hurria A, Jacobsen PB, Faul LA, Isaacs C, Denduluri N, Gavett B, Traina TA, Johnson P, Silliman RA, Turner RS, Howard D, Van Meter JW, Saykin A, Ahles T. Cognitive Impairment in Older Patients with Breast Cancer before Systemic Therapy: Is There an Interaction between Cancer and Comorbidity? J Clin Oncol. 2014 Jun 20;32(18):1909-18.

Schonberg MA, Birdwell RL, Bychkovsky B, Hintz L, Fein-Zachary V, Silliman RA.  Older women’s experience with breast cancer treatment decisions. Breast Cancer Res Treat. 2014 May;145(1):211-23.

Schonberg MA, Silliman RA, Ngo LH, Birdwell RL, Fein-Zachary V, Donato J, Marcantonio ER. Older women's experience with a benign breast biopsy—a mixed methods study. J Gen Intern Med. 2014 Dec;29(12):1631-40.

Caregivers

Wohlgemuth CM, Auerbach HP, & Parker VA. Advantages and Challenges: The Experience of Geriatrics Health Care Providers as Family Caregivers. Gerontologist. 2015 Aug;55(4):595-604.

Chronic Kidney Disease

Liu CK, Lyass A, Massaro JM, D'Agostino RB Sr, Fox CS, Murabito JM. Chronic kidney disease defined by cyst at in C predicts mobility disability and changes in gait speed: t he Framingham Offspring Study. J Gerontol A Biol Sci Med Sci. 2014 Mar;69(3):301-7.

Exceptional Longevity

Ash AS, Kroll-Desrosiers AR, Hoaglin DC, Christensen K, Fang H, Perls TT. Are Members of Long-Lived Families Healthier Than Their Equally Long-Lived Peers? Evidence From the Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):971-6.

Bae H, Perls T, Steinberg M, Sebastiani P. Bayesian Polynomial Regression Models to Fit Multiple Genetic Models for Quantitative Traits. Bayesian Anal. 2015 Mar;10(1):53-74.

Broer L, Buchman AS, Deelen J, Evans DS, Faul JD, Lunetta KL, Sebastiani P, Smith JA, Smith AV, Tanaka T, Yu L, Arnold AM, Aspelund T, Benjamin EJ, De Jager PL, Eirkisdottir G, Evans DA, Garcia ME, Hofman A, Kaplan RC, Kardia SL, Kiel DP, Oostra BA, Orwoll ES, Parimi N, Psaty BM, Rivadeneira F, Rotter JI, Seshadri S, Singleton A, Tiemeier H, Uitterlinden AG, Zhao W, Bandinelli S, Bennett DA, Ferrucci L, Gudnason V, Harris TB, Karasik D, Launer LJ, Perls TT, Slagboom PE, Tranah GJ, Weir DR, Newman AB, van Duijn CM, Murabito JM. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J Gerontol A Biol Sci Med Sci. 2015 Jan;70(1):110-8.

Honig LS, Kang MS, Cheng R, Eckfeldt JH, Thyagarajan B, Leiendecker-Foster C, Province MA, Sanders JL, Perls T, Christensen K, Lee JH, Mayeux R, Schupf N. Heritability of telomere length in a study of long-lived families. Neurobiol Aging. 2015 Oct;36(10):2785-90.

Minster RL, Sanders JL, Singh J, Kammerer CM, Barmada MM, Matteini AM, Zhang Q, Wojczynski MK, Daw EW, Brody JA, Arnold AM, Lunetta KL, Murabito JM, Christensen K, Perls TT, Province MA, Newman AB. Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index. J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):1003-8.

Nikolich-Žugich J, Goldman DP, Cohen PR, Cortese D, Fontana L, Kennedy BK, Mohler MJ, Olshansky SJ, Perls T, Perry D, Richardson A, Ritchie C, Wertheimer AM, Faragher RG, Fain MJ. Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society. J Gerontol A Biol Sci Med Sci. 2015 Sep 29. pii: glv164. 

Perls T, Handelsman DJ. Disease mongering of age-associated declines in testosterone and growth hormone levels. J Am Geriatr Soc. 2015 Apr;63(4):809-11.

Stevenson M, Bae H, Schupf N, Andersen S, Zhang Q, Perls T, Sebastiani P. Burden of disease variants in participants of the Long Life Family Study. Aging. 2015 Feb;7(2):123-32.

Sun F, Sebastiani P, Schupf N, Bae H, Andersen SL, McIntosh A, Abel H, Elo IT, Perls TT. Extended maternal age at birth of last child and women's longevity in the Long Life Family Study. Menopause. 2015 Jan;22(1):26-31.

Villa F, Carrizzo A, Spinelli CC, Ferrario A, Malovini A, Maciąg A, Damato A, Auricchio A, Spinetti G, Sangalli E, Dang Z, Madonna M, Ambrosio M, Sitia L, Bigini P, Calì G, Schreiber S, Perls T, Fucile S, Mulas F, Nebel A, Bellazzi R, Madeddu P, Vecchione C, Puca AA. Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis. Circ Res. 2015 Jul 31;117(4):333-45.

Zeng Y, Nie C, Min J, Liu X, Li M, Chen H, Xu H, Wang M, Ni T, Li Y, Yan H, Zhang JP, Song C, Chi LQ, Wang HM, Dong J, Zheng GY, Lin L, Qian F, Qi Y, Liu X, Cao H, Wang Y, Zhang L, Li Z, Zhou Y, Wang Y, Lu J, Li J, Qi M, Bolund L, Yashin A, Land KC, Gregory S, Yang Z, Gottschalk W, Tao W, Wang J, Wang J, Xu X, Bae H, Nygaard M, Christiansen L, Christensen K, Franceschi C, Lutz MW, Gu J, Tan Q, Perls T, Sebastiani P, Deelen J, Slagboom E, Hauser E, Xu H, Tian XL, Yang H, Vaupel JW. Novel loci and pathways significantly associated with longevity. Sci Rep. 2016 Feb 25;6:21243.

Ash A, Kroll-Desrosiers A, Hoaglin D, Christensen K, Fang H, Perls T. Are Members of Long-Lived Families Healthier Than Their Equally Long-Lived Peers? Evidence From the Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2015

Broer L, Buchman A, Deelen J, Evans D, Faul J, Lunetta K, Sebastiani P, Smith J, Smith A, Tanaka T, Yu L, Arnold A, Aspelund T, Benjamin E, De Jager P, Eirkisdottir G, Evans D, Garcia M, Hofman A, Kaplan R, Kardia S, Kiel D, Oostra B, Orwoll E, Parimi N, Psaty B, Rivadeneira F, Rotter J, Seshadri S, Singleton A, Tiemeier H, Uitterlinden A, Zhao W, Bandinelli S, Bennett D, Ferrucci L, Gudnason V, Harris T, Karasik D, Launer LJ, Perls T, Slagboom P, Tranah G, Weir D, Newman A, van Duijn C, Murabito J. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J Gerontol A Biol Sci Med Sci. 2015

Minster R, Sanders J, Singh J, Kammerer C, Barmada M, Matteini A, Zhang Q, Wojczynski M, Daw E, Brody J, Arnold A, Lunetta K, Murabito J, Christensen K, Perls T, Province M, Newman A. Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index. J Gerontol A Biol Sci. 2015

Perls T, Handelsman D. Disease Mongering of Age-Associated Declines in Testosterone and Growth Hormone Levels. J Am Geriatr Soc. 2015

Sebastiani P, Nussbaum L, Anderson SL, Black M, Perls T. Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of "Aging," "Life Span," and "Longevity". J Gerontol A Biol Sci Med Sci. 2015

Stevenson M, Bae H, Schupf N, Andersen S, Zhang Q, Perls T, Sebastiani P. Burden of disease variants in participants of the long life family study. Aging. 2015

Sun F, Sebastiani P, Schupf N, Bae H, Andersen S, McIntosh A, Abel H, Elo I, Perls T. Extended maternal age at birth of last child and women's longevity in the Long Life Family Study. Menopause. 2015

An P, Miljkovic I, Thyagarajan B, Kraja A, Daw E, Pankow J, Selvin E, Kao W, Maruthur N, Nalls M, Liu Y, Harris T, Lee J, Borecki I, Christensen K, Eckfeldt J, Mayeux R, Perls T, Newman A, Province M. Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS). Metabolism. 2014

Bae H, Perls T, Sebastiani P. An efficient technique for Bayesian modeling of family data using the BUGS software. Front Genet. 2014

Barral S, Cosentino S, Christensen K, Newman A, Perls T, Province M, Mayeux R; Long Life Family Study. Common genetic variants on 6q24 associated with exceptional episodic memory performance in the elderly. JAMA Neurol. 2014 

Sanders J, Minster R, Barmada M, Matteini A, Boudreau R, Christensen K, Mayeux R, Borecki I, Zhang Q, Perls T, Newman AB. Heritability of and mortality prediction with a longevity phenotype: the healthy aging index. J Gerontol A Biol Sci Med. 2014

Andersen S, Sun J, Sebastiani P, Huntly J, Gass J, Feldman L, Bae H, Christiansen L, Perls T. Personality factor in the Long Life Family Study. J Gerontol B Psych Sci Soc Sci. 2013

Bae H, Sebastiani P, Sun JX, Andersen S, Daw EW, Terracciano A, Ferrucci L, Perls T. Gerome-wide association study of personality traits in the long life family study. Front Genet. 2013

Barral S, Cosentino S, Costa R, Andersen S, Christensen K, Eckfeldt J, Newman A, Perls T, Province M, Hadley E, Rossi W, Mayeux R; Long Life Family Study. Exceptional memory performance in the Long Life Family Study. Neurobiol Aging. 2013

Elo IT, Mykyta L, Sebastiani P, Christensen K, Glynn NW, Perls T. Age validation in the long life family study through a linkage to early-life census records. J Gerontol B Psychol Sci Soc Sci. 2013

Kaufman LB, Setiono TK, Doros G, Andersen S, Silliman RA, Friedman PK, Perls TT. An oral health study of centenarians and children of centenarians. J Am Geriatr Soc 2014;62:1168-73

Lee J, Cheng R, Honig L, Feitosa M, Kammerer CM, Kang M, Schupf N, Lin S, Sanders L, Bae H, Druley T, Perls T, Christensen K, Province M, Mayeux R. Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. Front Genet. 2014

Perls T. The reappearance of procaine hydrochloride (Gerovital H3) for antiaging. J Am Geriatr Soc. 2013

Schupf N, Barral S, Perls T, Newman A, Christensen K, Thyagarajan B, Province M, Rossi W, Mayeux R. Apolopoprotein E and familial longevity. Neurobiol Aging. 2013

Sebastiani P, Bae H, Sun F, Andersen S, Daw EW, Malovini A, Kojima T, Hirose N, Schupf N, Puca A, Perls T. Meta‐analysis of genetic variants associated with human exceptional longevity. Aging 2013

Sebastiani P, Sun F, Andersen S, Lee J, Wojczynski M, Sanders J, Yashin A, Newman A, Perls T. Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study. Front Public Health. 2013

Exercise in the Elderly

Vaz Fragoso CA, Miller ME, King AC, Kritchevsky SB, Liu CK, Myers VH, Nadkarni NK, Pahor M, Spring BJ, Gill TM; Lifestyle Interventions and Independence for Elders Study Group. Effect of Structured Physical Activity on Sleep-Wake Behaviors in Sedenray Elderly Adults with Mobility Limitations. J Am Geriatr Soc. 2015 Jul;63(7):1381-90.

Liu CK, Leng X, Hsu FC, Kritchevsky SB, Ding J, Earnest CP, Ferrucci L, Goodpaster BH, Guralnik, JM, Lenchik L, Pahor M,  Fielding RA. The impact of sarcopenia on a physical activity intervention: The Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). J Nut Health Aging. 2014. 18(1):59-64.

Liu CK,  Fielding RA. Exercise as an intervention for frailty. Clin Geriatr Med. 2011 Feb;27(1):101-10.

Frailty

Liu CK, Lyass A, Larson MG, Massaro JM, Wang N, D'Augusto RB, Benjamin EJ, Murabito JM. Biomarkers of oxidative stress are associated with frailty: the Framingham Offspring Study. Age (Dordr). 2016 Feb;38(1):1.

Misra D, Felson DT, Silliman RA, Nevitt M, Lewis CE, Torner J, Neogi T. Knee osteoarthritis and frailty: findings from the Multicenter Osteoarthritis Study and Osteoarthritis Initiative. J Gerontol A Biol Sci Med Sci. 2015 Mar;70(3):339-44.

Geriatrics Education

Gillespie SM, Brandt LE, Chang A, Chao SH, Corcoran AM, Miller R, Harper GM, Levine SA, Medina-Walpole A. Staying in the game: the 10-step approach to sustaining geriatrics education in hospitalists and subspecialty providers. J Am Geriatr Soc. 2014 Aug;62(8):1575-82.

Leipzig RM, Sauvigné K, Granville LJ, Harper GM, Kirk LM, Levine SA, Mosqueda L, Parks SM, Fernandez HM, Busby-Whitehead J. What is a geriatrician? American Geriatrics Society and Association of Directors of Geriatric Academic Programs end-of-training Entrustable Professional Activities for geriatric medicine. J Am Geriatr Soc. 2014 May;62(5):924-9.

Kleber KT, Young ME, Zumwalt AC. Interprofessional Collaboration Enables Integration of Basic Science Content into Clinical Education. Med Sci Educ 2013; 23 (3S). Interprofessional Collaboration Enables Integration of Basic Science Content into Clinical Education. Med Sci Educ. 2013; 23(3S):426-428.

Chao SH, Brett B, Wiecha JM, Norton LE, Levine SA. Use of an Online Curriculum to Teach Delirium to Fourth-Year Medical Students: A Comparison with Lecture Format. J Am Geriatr Soc. 2012 Jul;60(7):1328-32.

Suen W, Parker VA, Harney L, Nevin S, Jansen J, Alexander L, Berlowitz D. Internal Medicine Interns’ and Residents’ Pressure Ulcer Prevention and Assessment Attitudes and Abilities: Results of an Exploratory Study. Ostomy Wound Manage. 2012 Apr;58(4):28-35.

Auerbach H, Lee W. "Evaluating Your Practice." Geriatric Care by Design: A Clinician’s Handbook to Meet the Needs of Older Adults through Environmental and Practice Redesign. Chicago, IL American Medical Association, 2011.

Auerbach H, Lee W, Kelly P. "Patient, Staff, and Personal Satisfaction." Geriatric Care by Design: A Handbook to Meet the Needs of Older Adults through Environmental and Practice Redesign. Chicago, IL. American Medical Association, 2011.

Caruso L, Auerbach H, McDonough A. "Developing a Plan to Assess Your Practice." Geriatric Care by Design: A Handbook to Meet the Needs of Older Adults through Environmental and Practice Redesign. Chicago, IL. American Medical Association, 2011.

Kopits I, “Evaluating Your Practice.” Geriatric Care by Design: A Handbook to Meet the Needs of Older Adults through Environmental and Practice Redesign. Chicago, IL: American Medical Association, 2011.

Lee W, Oates D. “Patient Educational Materials.” Geriatric Care by Design: A Handbook to Meet the Needs of Older Adults through Environmental and Practice Redesign. Chicago, IL. American Medical Association, 2011.

Hospitalizations

Goldenheim A, Oates D, Parker V, Russell M, Winter M, Silliman RA. Rehospitalization of Older Adults Discharged to Home Hospice Care. J Palliat Med. 2014 Jul;17(7):841-4.

Oates D, Kornetsky D, Winter M, Silliman R, Caruso L, Hardt E, Sharbaugh M, Parker V. Minimizing Geriatric Rehospitalizations: A Successful Clinical Model. Am J Med Qual. 2013 Jan-Feb;28(1):8-15.

Internal Medicine

Shalaby M, Yaich S, Donnelly J,  Chippendale R, DeOliveira MC, Noronha C. X + Y Scheduling Models for Internal Medicine Residency Programs—A Look Back and a Look Forward. J Grad Med Educ. 2014 Dec; 6(4): 639–642. 

Weigel C, Suen W, Gupte G. Using Lean Methodology to Teach Quality Improvement to Internal Medicine Residents at a Safety Net Hospital. Am J Med Qual. 2013 Sep-Oct;28(5):392-9.

Mobility

Kirn DR, Koochek A, Reid KF, Von Berens A, Travison TG, Folta S, Sacheck J, Nelson M, Liu C, Phillips E, Aberg AC, Nydahl M, Gustafsson T, Cederholm T, Fielding RA. The Vitality, Independence, and Vigor in the Elderly 2 Study (VIVE2): Design and methods. Contemp Clin Trials. 2015 Jul;43:164-71. 

Mankowski RT, Aubertin-Leheudre M, Beavers DP, Botoseneanu A, Buford TW, Church T, Glynn NW, King AC, Liu C, Manini TM, Marsh AP, McDermott M, Nocera JR, Pahor M, Strotmeyer ES, Anton SD; LIFE Research Group. Sedentary time is associated with the metabolic syndrome in older adults with mobility limitationsThe LIFE Study. Exp Gerontol. 2015 Oct;70:32-6.

Vaz Fragoso CA, Hsu FC, Brinkley T, Church T, Liu CK, Manini T, Newman AB, Stafford RS, McDermott MM, Gill TM; LIFE Study Group. Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations. J Am Med Dir Assoc. 2014 Sep;15(9):665-70.

McDonough CM, Tian F, Ni P, Kopits IM, Moed R, Pardasaney PK, Jette AM. Development of the Computer-Adaptive Version of the Late-Life Function and Disability Instrument. J Gerontol A Biol Sci Med Sci. 2012 Dec;67(12):1427-38.

Nursing Homes

Caruso LB, Thwin SS, Brandeis GH. Following Up on Clinical Recommendations in Transitions from Hospital to Nursing Home. J Aging Res. 2014;2014:873043.

Alfarah, Z, Ramadan FH, Cury E, Brandeis GH. Muslim Nursing Homes in the United States: Barriers and Prospects. J Am Med Dir Assoc. 2012 Feb;13(2):176-9. 

Patient Relations

Mostow C, Crosson J, Gordon S, Chapman S, Hardt E, James T, Gonzalez P. R-E-S-P-E-C-T: physician-patient communication. J Gen Intern Med. 2014 Aug

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Call: 617.414.4639
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Geriatrics Clinic
Shapiro Center
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Boston, MA 02118

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