MONTY A. MONTANO, PH.D.
Assistant Professor of Medicine
Center for HIV/AIDS Care and Research
Boston Medical Center
650 Albany Street, EBRC 646
Boston, MA 02118
B.S. University of California, Berkeley
Ph.D. Stanford University
The Montano laboratory is broadly interested in HIV pathogenesis, muscle biology, and aging. Research initiatives in the Montano laboratory include analysis of host genes and molecular mechanisms engaged during HIV-1 infection and transmission, the interaction between host immune factors (e.g., macrophages) and muscle stem cell remodeling during HIV associated wasting, and the molecular phenotyping of aging and longevity. The laboratory utilizes tools in molecular virology, quantitative analysis of gene and protein expression, and genome-wide microarray analysis to better understand genotypic and phenotypic associations with human health and disease.
Dr. Montano is currently (2007-2012) the principal investigator of a NIAMS-sponsored R01 research grant entitled, “Macrophage-Muscle Precursor Cell Interactions in the Context of HIV Infection.” Dr. Montano recently completed (2003-2007) his NIAID-sponsored R01 research grant entitled, "Molecular Analysis of HIV-1C Transmission Cofactors." This study evaluated the role of the maternal gene expression profile in HIV-1 perinatal transmission in Botswana, Africa.
- Montano M, Flanagan JN, Jiang L, Sebastiani P, Rarick M, LeBrasseur NK, Morris CA, Jasuja R, Bhasin S. Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. Epub 2007 Apr 17.
- Montano M, Rarick M, Sebastiani P, Brinkmann P, Russell M, Navis A, Wester C, Thior I, Essex M. Gene-expression profiling of HIV-1 infection and perinatal transmission in Botswana. Genes Immun. 2006 Jun;7(4):298-309. Epub 2006 May 4.
- Rarick M, McPheeters C, Bright S, Navis A, Skefos J, Sebastiani P, Montano M. Evidence for cross-regulated cytokine response in human peripheral blood mononuclear cells exposed to whole gonococcal bacteria in vitro. Microb Pathog. 2006 Jun;40(6):261-70. Epub 2006 Apr 19.
- Montano M, Rarick M, Sebastiani P, Brinkmann P, Skefos J, Ericksen R. HIV-1 burden influences host response to co-infection with Neisseria gonorrhoeae in vitro. Int Immunol. 2006 Jan;18(1):125-37. Epub 2005 Dec 13.
- Montano MA, Nixon CP, Essex M. Dysregulation through the NF-kappaB enhancer and TATA box of the human immunodeficiency virus type 1 subtype E promoter. J Virol. 1998 Oct;72(10):8446-52.
- Montano MA, Novitsky VA, Blackard JT, Cho NL, Katzenstein DA, Essex M. Divergent transcriptional regulation among expanding human immunodeficiency virus subtypes. J Virol. 1997 Nov;71(11):8657-65.